Eric M. Snyder, PhD, Jan Stepanek, MD, Sheryl L. Bishop, PhD, Bruce D

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Presentation transcript:

Ventilatory Responses to Hypoxia and High Altitude During Sleep in Aconcagua Climbers Eric M. Snyder, PhD, Jan Stepanek, MD, Sheryl L. Bishop, PhD, Bruce D. Johnson, PhD Wilderness & Environmental Medicine Volume 18, Issue 2, Pages 138-145 (June 2007) DOI: 10.1580/06-WEME-BR-041R.1 Copyright © 2007 Wilderness Medical Society Terms and Conditions

Figure 1 Changes in oxygen saturation and symptoms (Lake Louise score) with exposure to normoxia, simulated 4300m, and 3 increasing altitudes. The top panel represents the oxygen saturation, while the bottom panel represents the Lake Louise score. The X-axis represents the condition. Wilderness & Environmental Medicine 2007 18, 138-145DOI: (10.1580/06-WEME-BR-041R.1) Copyright © 2007 Wilderness Medical Society Terms and Conditions

Figure 2 Changes in ventilation during sleep with exposure to normoxia, simulated 4300m, and 3 increasing altitudes. The X-axis represents the variable assessed, the Y-axis represents the condition, and the Z-axis represents the percent change from normobaric normoxia. The open bars represent change in ventilation, the black-filled bars represent the change in respiratory rate, and the gray-filled bars represent the change in tidal volume. Wilderness & Environmental Medicine 2007 18, 138-145DOI: (10.1580/06-WEME-BR-041R.1) Copyright © 2007 Wilderness Medical Society Terms and Conditions

Figure 3 Relationship between oxygen saturation and ventilation and ventilatory drive. The top graph represents the relationship between changes in oxygen saturation and ventilation; the bottom graph represents the relationship between changes in oxygen saturation and ventilatory drive (VT/Ti). Wilderness & Environmental Medicine 2007 18, 138-145DOI: (10.1580/06-WEME-BR-041R.1) Copyright © 2007 Wilderness Medical Society Terms and Conditions

Figure 4 Example of periodic breathing (PB) in both climbers during simulated 4300m and at 5900m. The top 2 figures represent an example of PB during sleep in climber A, while the bottom graph represents an example of this breathing pattern in climber B, both at simulated 4300m and 5900m, respectively. The top segment of both graphs is a tracing of that individual's tidal volume, the second segment represents O2sat, the third segment heart rate, and the fourth segment ventilatory drive (VT/ Ti). Wilderness & Environmental Medicine 2007 18, 138-145DOI: (10.1580/06-WEME-BR-041R.1) Copyright © 2007 Wilderness Medical Society Terms and Conditions

Figure 4 Example of periodic breathing (PB) in both climbers during simulated 4300m and at 5900m. The top 2 figures represent an example of PB during sleep in climber A, while the bottom graph represents an example of this breathing pattern in climber B, both at simulated 4300m and 5900m, respectively. The top segment of both graphs is a tracing of that individual's tidal volume, the second segment represents O2sat, the third segment heart rate, and the fourth segment ventilatory drive (VT/ Ti). Wilderness & Environmental Medicine 2007 18, 138-145DOI: (10.1580/06-WEME-BR-041R.1) Copyright © 2007 Wilderness Medical Society Terms and Conditions

Figure 5 Amount of periodic breathing during sleep with exposure to normoxia, simulated 4300m, and 3 increasing altitudes. The top graph is the average amount of apneas observed per hour in both climbers. The bottom graph is the average amount of time periodic breathing during rest and sleep in both climbers. The X-axis represents the condition. Wilderness & Environmental Medicine 2007 18, 138-145DOI: (10.1580/06-WEME-BR-041R.1) Copyright © 2007 Wilderness Medical Society Terms and Conditions