Electro-osmotic drug delivery technology

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Presentation transcript:

Electro-osmotic drug delivery technology Ceramatec Inc. 2425 S. 900 W. Salt Lake City, Utah 84119

Implantable electro osmotic pump Driven galvanically by two electrodes on board that controllably promote electro-osmosis Fluid is pumped from the body into a chamber, expelling the contents controllably from a drug reservoir Catheter from pump can be routed to treatment site Pump can be remotely controlled Successfully demonstrated in rabbits Implantation site after 8 weeks delivery Applications? Chronic pain Anti-biotics Hormones RNA therapy Intra cranial delivery Ceramatec Business Proprietary

Ceramatec Business Proprietary What does device do? Device with drug is implanted into the body Device delivers drug over slow steady rate 0.5 to 10 µL per hour Week to months duration Rate is controllable and can be shut off or turned on from out side the body Ceramatec Business Proprietary

Ceramatec Business Proprietary What is the advantage? Size efficiency Low rate capable Shut off capability No need to explant if adverse drug reaction occurs Reduced infection No penetration through skin to infect Convenient Device can be placed near the skin surface for easy shut off and catheter routed to target area Ceramatec Business Proprietary

How does the technology work? Water and ions from the body electro-osmotically pass through a membrane and enter a chamber AgCl + e- → Ag + Cl- ½ Zn → ½ Zn++ + e- AgCl + ½ Zn + → Ag + ½ ZnCl2 Na+ + water pass through cation exchange membrane e- flows through circuit e- e- Ceramatec Business Proprietary

How does the technology work? The water and ions press on a flexible member and force the drug through a catheter Ceramatec Business Proprietary

How does the technology work? Rate is determined by the resistance of an electrical circuit between galvanic electrodes Device is shut off when circuit is opened by any of several methods Sealed latching magnetic switch Ceramatec Business Proprietary

Fast Shut-off Response Compartmentalization Peclet number – Pe = transport due to convection/transport due to diffusion = Q x L / N x D x A Q = flux L = flow channel length N = number of channels D = diffusion coefficient A = area of individual channels In vitro testing Faster response found with rising Pe # <15 minute shut off Ceramatec Business Proprietary

Has the device been tested invivo? 3 rabbit models have been studied, each with design improvements E-beam sterilized Devices delivered at 1.4 µL per hour over 8 weeks Histopathology showed no adverse tissue reactions around implant Ceramatec Business Proprietary

Electro-osmotic summary Implantable technology developed to deliver at low rates over several weeks to months Utilizes electro-osmosis Very small volume relative to payload Can be turned on and off after implantation Negligible interaction with tissues Implantation site after 8 weeks delivery Ceramatec Business Proprietary

What are contemplated applications? Delivery of pain medication to spine Delivery of anti-biotics to internal infections Delivery of chemotherapy drugs to tumors or cancers We welcome your thoughts regarding the best uses of this technology What drugs? What therapies? Ceramatec Business Proprietary

Drug delivery technologies What Ceramatec is seeking: Specific applications Strategic partners for specific applications Ceramatec Business Proprietary

Ceramatec Business Proprietary Contact information John Gordon Ceramatec Inc. 2425 South 900 West Salt Lake City, UT 84119 USA 801-972-2455 cell: 303-915 -7724 johng@ceramatec.com www.ceramatec.com Ceramatec Business Proprietary