E. Cendejas-Bueno, A. Forastiero, J. L. Rodriguez-Tudela, M

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Presentation transcript:

HPLC/UV or bioassay: two valid methods for posaconazole quantification in human serum samples E. Cendejas-Bueno, A. Forastiero, J.L. Rodriguez-Tudela, M. Cuenca-Estrella, A. Gomez-Lopez Clinical Microbiology and Infection Volume 18, Issue 12, Pages 1229-1235 (December 2012) DOI: 10.1111/j.1469-0691.2011.03732.x Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Posaconazole bioassay linearity and calibration curve. Clinical Microbiology and Infection 2012 18, 1229-1235DOI: (10.1111/j.1469-0691.2011.03732.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Scatter plot of posaconazole (PSZ) serum concentrations (μg/mL) measured by HPLC and bioassay. Linear regression: Bioassay = 0.7425 (HPLC) + 0.026; R2 = 0.871, with a coefficient of correlation = 0.931; n = 61 runs. Clinical Microbiology and Infection 2012 18, 1229-1235DOI: (10.1111/j.1469-0691.2011.03732.x) Copyright © 2012 European Society of Clinical Infectious Diseases Terms and Conditions