Volume 127, Issue 2, Pages 444-451 (August 2004) Genetic testing and phenotype in a large kindred with attenuated familial adenomatous polyposis  Randall W. Burt, Mark F. Leppert, Martha L. Slattery, Wade S. Samowitz, Lisa N. Spirio, Richard A. Kerber, Scott K. Kuwada, Deborah W. Neklason, James A. DiSario, Elaine Lyon, J.Preston Hughes, William Y. Chey, Raymond L. White  Gastroenterology  Volume 127, Issue 2, Pages 444-451 (August 2004) DOI: 10.1053/j.gastro.2004.05.003

Figure 1 Number of adenomatous polyps in mutation-positive individuals as a function of age. The maximum numbers of adenomatous polyps found in the colon during a single endoscopic or surgical procedure are plotted against the age of the individual at the time of the procedure. Each individual is represented by a square (n = 120). Black squares represent individuals from K353(B). Gray squares represent individuals from K353(E). White squares represent individuals from K439. Those with 100 or more polyps were set at 100 polyps. Gastroenterology 2004 127, 444-451DOI: (10.1053/j.gastro.2004.05.003)

Figure 2 CRC-free survival curves by age in AFAP kindreds and the Utah Population Database. Kaplan-Meier survival curves for CRC-free survival in mutation-positive AFAP kindred members (K353/K439; solid line) and the Utah Population Database population (UPDB; dotted line) were calculated for invasive CRC as described in Methods. The 95% confidence interval (CI) for mutation-positive AFAP kindred members is indicated by the dashed line. The number of observations for CRC in the AFAP kindreds, as age progresses, are indicated. Note that the CRC-free survival at age 80 is 31% (CRC risk, 69%). Gastroenterology 2004 127, 444-451DOI: (10.1053/j.gastro.2004.05.003)