A Radical Bailout Strategy for Cancer Stem Cells Zuzana Tothova, D. Gary Gilliland  Cell Stem Cell  Volume 4, Issue 3, Pages 196-197 (March 2009) DOI: 10.1016/j.stem.2009.02.008 Copyright © 2009 Elsevier Inc. Terms and Conditions

Figure 1 Breast CSCs Exhibit Low Levels of ROS and Increased Radiation Resistance Treatment of breast tumors with ionizing radiation (IR) results in selective survival of breast cancer stem cells (CSCs; left), but not their nontumorigenic counterparts (top). Glutathione (GSH) synthesis, regulated by Gclm (glutamate cysteine ligase) and Gss (glutathione synthetase), and transcription factor FoxO1, is reduced following treatment with buthionine sulphoximine (BSO) and results in increased levels of ROS, radiosensitization of breast CSCs, and abolishment of selective survival of breast CSCs in the presence of IR (right). Cell Stem Cell 2009 4, 196-197DOI: (10.1016/j.stem.2009.02.008) Copyright © 2009 Elsevier Inc. Terms and Conditions