In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation by Panagiotis D. Kottaridis, Donald W. Milligan,

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Presentation transcript:

In vivo CAMPATH-1H prevents graft-versus-host disease following nonmyeloablative stem cell transplantation by Panagiotis D. Kottaridis, Donald W. Milligan, Rajesh Chopra, Ronjon K. Chakraverty, Suparno Chakrabarti, Stephen Robinson, Karl Peggs, Stephanie Verfuerth, Ruth Pettengell, Judith C. W. Marsh, Stephen Schey, Premini Mahendra, Gareth J. Morgan, Geoff Hale, Herman Waldmann, M. Carmen Ruiz de Elvira, Catherine D. Williams, Stephen Devereux, David C. Linch, Anthony H. Goldstone, and Stephen Mackinnon Blood Volume 96(7):2419-2425 October 1, 2000 ©2000 by American Society of Hematology

Microsatellite analyses Microsatellite analyses.(A) Full-donor chimerism in all 3 lineages; (B) mixed chimerism in all 3 lineages; and (C) mixed T-cell chimerism (arrow shows recipient T-cell marker) with full-donor chimerism and B cells and granulocytes. Microsatellite analyses.(A) Full-donor chimerism in all 3 lineages; (B) mixed chimerism in all 3 lineages; and (C) mixed T-cell chimerism (arrow shows recipient T-cell marker) with full-donor chimerism and B cells and granulocytes. Panagiotis D. Kottaridis et al. Blood 2000;96:2419-2425 ©2000 by American Society of Hematology

Kaplan-Meier curves.(A) Nonrelapse mortality; (B) progression-free mortality; and (C) overall survival for the entire group of 44 patients. Kaplan-Meier curves.(A) Nonrelapse mortality; (B) progression-free mortality; and (C) overall survival for the entire group of 44 patients. Panagiotis D. Kottaridis et al. Blood 2000;96:2419-2425 ©2000 by American Society of Hematology