Diffuse depigmentation in a patient with chronic myeloid leukemia

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Diffuse depigmentation in a patient with chronic myeloid leukemia Chih-Chieh Chan, MD, Ming Yao, MD, Tsen-Fang Tsai, MD Journal of the American Academy of Dermatology Volume 54, Issue 4, Pages 738-740 (April 2006) DOI: 10.1016/j.jaad.2005.07.053 Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Diffuse hypopigmentation of the skin. Darker brownish macules/islands represent original normal skin color. Note white eyebrows and beard. Journal of the American Academy of Dermatology 2006 54, 738-740DOI: (10.1016/j.jaad.2005.07.053) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Histopathologic studies of hypopigmented skin. A, Normal-appearing epidermis and basal layer. B, Number of melanocytes is decreased in basal layer; hypodendricity of lesional melanocytes is shown in inset (arrows). C, Diffuse hypomelanosis is noted in entire layer of epidermis. (A, Hematoxylin-eosin stain; B, S-100 stain; C, Fontana-Masson stain; original magnifications: A and C, ×200; B, ×200 [inset ×400].) Journal of the American Academy of Dermatology 2006 54, 738-740DOI: (10.1016/j.jaad.2005.07.053) Copyright © 2006 American Academy of Dermatology, Inc. Terms and Conditions