Dendritic cells and lymphoma cells: come together right now

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Presentation transcript:

Dendritic cells and lymphoma cells: come together right now by Nina Bhardwaj, and Joshua D. Brody Blood Volume 125(1):5-7 January 1, 2015 ©2015 by American Society of Hematology

These similar approaches of bringing together DCs and tumor antigens have been tested clinically. These similar approaches of bringing together DCs and tumor antigens have been tested clinically. Each approach differs in the site and technique of isolating, loading, and activating DCs, by either ex vivo Percoll and metrizamide gradient separation with ex vivo Id pulsing4; ex vivo monocyte culture in GM-CSF/IL-4 with ex vivo apoptotic tumor pulsing5; in vivo (scarce) DCs and (abundant) tumor B-cell TLR activation with in vivo tumor irradiation7; ex vivo monocyte culture in GM-CSF/IL-4 with in vivo tumor irradiation, GM-CSF, and rituximab1; or in vivo Flt3L-mobilized DCs with in vivo tumor irradiation and TLR activation. NCT01976585 refers to the trial registry number (clinicaltrials.gov) of a clinical trial currently in progress. Flt3L, FMS-related tyrosine kinase 3 ligand. Professional illustration by Luk Cox, Somersault 18:24. Nina Bhardwaj, and Joshua D. Brody Blood 2015;125:5-7 ©2015 by American Society of Hematology