The REDOXS© Study REducing Deaths from OXidative Stress Part 2 of 3

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The REDOXS© Study REducing Deaths from OXidative Stress PART 3 of 4
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The REDOXS© Study REducing Deaths from OXidative Stress Part 2 of 3 REDOXS Training The REDOXS© Study REducing Deaths from OXidative Stress Part 2 of 3 Sponsor Dr. Daren Heyland, MD, FRCPC Project Leader Rupinder Dhaliwal, BASc, RD October 2007

Role of the Dietitian

Optimizing Enteral Nutrition Canadian CPGs www.criticalcarenutrition.com Feeding Protocol Glycemic Protocol Elevate the Head of the Bed Motility Agents Small Bowel Feeding

Maximize EN nutrient and nutrition delivery RD Manual p 12-17 Maximize EN nutrient and nutrition delivery use of feeding protocols small bowel feeding Minimize interruptions, make up volume Other enteral formulas with supplemental glutamine, vitamins, minerals not allowed No supplements with high amounts of Zinc (5 mg max) Renal Dysfunction Switch to lower protein formula Restrict fluid Refer to appendix (p 14) Pilot study: Interruptions due to high urea only in 2% patient days (9% patients)

RD manual p 13 SS Manual p 16

Baseline Nutrition Dietitian to collect RD Manual p 5,6 Imp Manual p 29,30 Dietitian to collect Prescribed kcal and protein (baseline) Type of nutrition support Start and stop date and times Refer to Dietitian Manual

Collection in real time essential ! Daily Nutrition Data RD Manual p 7,11 Imp Manual p 37-39 Dietitian to collect (for max 30 days): Energy protein intake Add propofol Interruptions Type of enteral formula + location of feeding tube (daily data Collection in real time essential !

Dietitian Checklist Imp Manual: Tools RD Manual: 19,20

Study Supplement Compliance Study coordinator collects Received MUST = prescribed volumes Inform Study Coordinator of interruptions Work with bedside RN Protocol Violation Protocol Deviation Imp Manual p 34

Case study: High GRVs Mr. Smith who is 4 days post laporotomy (findings show bowel is not compromised) has had high gastric residual volumes > 500 mls for the last 48 hours. His enteral feeds have been interrupted several times and are now on hold. The MD in charge has also stopped the enteral study supplements to give the gut a rest and he now wishes to start parenteral nutrition. What to do?

FAQs Do I calculate the calories from propofol if patients are not receiving enteral or parenteral nutrition? What if the prescribed calories and protein changes over the 28 days of the study duration? How do I get a prescribed calorie/protein level if the dietitian has not assessed this?

Case Study: Dosing error REDOXS Pharmacist away for weekend and returns on Monday and after reviewing logs realizes that Mr. J.S accidentally received the wrong supplements. Should have received GLN but received GLN+AOX instead for the last 18 hours. What to do? Stop the infusion immediately Inform research coordinator ASAP, maintain blinding Notify CERU immediately, Note to File Steps to prevent recurrence

FAQs Pharmacy Keep vials of returned/destroyed products? One password for all Pharmacists/technicians? Pharmacist or technician that dispenses the supplements? P. Manual page 16

REDOXS© Circular and Bulletin Questions?? Imp Manual Tools REDOXS© Circular and Bulletin