Nerve and Muscle Physiology

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Presentation transcript:

Nerve and Muscle Physiology Plasma Membranes of Excitable tissues Ref: Guyton, 12th ed: pp: 57-69. 11th ed: p57-71,

Fig. 12.09a,b

Nernest equation

Ek+ E (mV) = - 61.log (Ci/Co) E = Equilibrium potential for a univalent ion Ci = conc. inside the cell. Co = conc. outside the cell.

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Goldman-Hodgkin-Katz equation EMF (mV) = - 61. log [( CiNa+. PNa+ + CiK+. PK+ + CoCl- .PCl- ) (CoNa+ PNa+ + CoK+ PK+ + CiCl- PCl-)] Ci = Conc. inside Co = Conc. outside P = permeability of the membrane to that ion.