Enzymatic reactions catalyzed by wild-type and mutant IDH enzymes.

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Enzymatic reactions catalyzed by wild-type and mutant IDH enzymes. Enzymatic reactions catalyzed by wild-type and mutant IDH enzymes. Top: wild-type IDH1 and IDH2 convert isocitrate to α-KG and CO2, with concomitant production of NADPH from NADP. Bottom: tumor-associated mutant IDH1 and IDH2 enzymes convert α-KG to D2HG, with concomitant production of NADP from NADPH. D2HG is a chiral molecule very similar in structure to α-KG. The chiral center in D2HG is denoted by *. Rob A. Cairns, and Tak W. Mak Cancer Discovery 2013;3:730-741 ©2013 by American Association for Cancer Research