SD-IAP č.275, M2801/04 Ondič O., ŠPAU Plzeň.

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SD-IAP č.275, M2801/04 Ondič O., ŠPAU Plzeň

Žena 47 rokov. Konizát krčka maternice. Klinické údaje Žena 47 rokov. Konizát krčka maternice.

Vaša diagnóza ?

?

Adenokarcinom in situ typu SMILE a typu intestinálneho Stratified mucinous intraepithelial lesion Park,AJSP,2000

SMILE,Jeong-Ja Park, AJSP,2000 Mucín a CIN - História Mucin production in mixed carcinoma of the uterine cervix, Benda, Int J Gynecol Pathol, 1985 Mucin production in CIN and carcinoma stage 1b, Ireland,Br J Obstret Gynaecol, 1987 Muco-epidermoid carcinoma of cervix, Buckley, in Coppleson, Gynecologic oncology1992 SMILE,Jeong-Ja Park, AJSP,2000

Súčasný stav Surgical Pathology, Fletcher, 3rd ed.,2007: Squamomucinous /stratified in situ adenocarcinoma. Diagnostic gynecologic and obstetric pathology, Crum,2007: Stratified in situ adenocarcinoma.

Adenocarcinoma in situ: Crum Adenocarcinoma in situ: endocervical endometrioid intestinal stratified ciliated

Fletcher Adenocarcinoma in situ: endocervical endometrioid intestinal squamomucinous/stratified ciliated

MUC2 - pohárikovité bunky MUC6, HIK1083 – žliazky gastrického typu Histochémia MUC2 - pohárikovité bunky MUC6, HIK1083 – žliazky gastrického typu

Genetika Somatické mutácie: KRAS (13.9%), BRAF (4.3%) ( RAS/RAF/MAPK cesta) Metylácia promotoru génu: RASSFIA (23.5 %) ( väzobný proteín pre RAS)

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