Treatment of chronic rhinosinusitis with intranasal amphotericin B: A randomized, placebo-controlled, double-blind pilot trial Jens U. Ponikau, MD, David.

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Presentation transcript:

Treatment of chronic rhinosinusitis with intranasal amphotericin B: A randomized, placebo-controlled, double-blind pilot trial Jens U. Ponikau, MD, David A. Sherris, MD, Amy Weaver, MS, Hirohito Kita, MD Journal of Allergy and Clinical Immunology Volume 115, Issue 1, Pages 125-131 (January 2005) DOI: 10.1016/j.jaci.2004.09.037 Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 1 Procedure to obtain objective measurement of inflammatory mucosal thickening from a coronal CT scan. A, Standardized cuts through the middle meatus that were digitized for comparison. B, Example of the area representing the airspace (blue). C, Area representing the inflammatory mucosal thickening (yellow). Once digitized, this area provides an objective quantitation of inflammatory mucosal thickening. Journal of Allergy and Clinical Immunology 2005 115, 125-131DOI: (10.1016/j.jaci.2004.09.037) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions

Fig 2 Changes from baseline in the percentage of inflammatory mucosal thickening. As measured by CT scan, the relative changes in thickening that occlude the nasal and paranasal cavities are shown after 6 months of treatment (primary endpoint). Each dot represents an individual patient. A negative change from baseline indicates a decrease in mucosal thickening. Horizontal lines represent the means for each group. Journal of Allergy and Clinical Immunology 2005 115, 125-131DOI: (10.1016/j.jaci.2004.09.037) Copyright © 2005 American Academy of Allergy, Asthma and Immunology Terms and Conditions