J. Rautiainen, M. T. Nieminen, E. -N. Salo, H. T. Kokkonen, S

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Effect of collagen cross-linking on quantitative MRI parameters of articular cartilage J. Rautiainen, M.T. Nieminen, E.-N. Salo, H.T. Kokkonen, S. Mangia, S. Michaeli, O. Gröhn, J.S. Jurvelin, J. Töyräs, M.J. Nissi Osteoarthritis and Cartilage Volume 24, Issue 9, Pages 1656-1664 (September 2016) DOI: 10.1016/j.joca.2016.04.017 Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Osteochondral plugs of 25.4 mm in diameter were prepared from intact bovine patellae (n = 7). The MRI samples were prepared from tissue adjacent to that used in biomechanical testing and CECT measurements in another study. The plugs were divided into four adjacent samples of equal size for the CT and biomechanical measurements. For MRI, two smaller triangle-shaped osteochondral samples (6 mm wide) were detached from the larger pieces of the biomechanical group. For biomechanical testing and other reference analyses, osteochondral plugs of 6 mm in diameter were punched from the same piece. Osteoarthritis and Cartilage 2016 24, 1656-1664DOI: (10.1016/j.joca.2016.04.017) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Mean depth-wise profiles of MRI relaxation time parameters (adiabatic T1ρ, CW-T1ρ (spin-lock frequencies 1000, 500, 250 and 125 Hz), adiabatic T2ρ, DE-T2, pre-contrast T1, T1,Gd and T1sat) and ΔR1 in bovine articular cartilage of threose (dashed line) and non-treated (solid line) sample groups. All profiles were linearly interpolated to normalized length of 20 pixels. Osteoarthritis and Cartilage 2016 24, 1656-1664DOI: (10.1016/j.joca.2016.04.017) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Representative MRI relaxation time maps (adiabatic T1ρ, CW-T1ρ (spin-lock frequencies 1000, 500, 250 and 125 Hz) adiabatic T2ρ, DE-T2, T1, T1Gd, T1sat) of threose treated and non-treated bovine articular cartilage samples. CW-T1ρ varies with spin-locking frequency showing T2-like laminar structure at lowest spin-lock power. Significant prolongation of T1,Gd is noted in the threose treated sample. Osteoarthritis and Cartilage 2016 24, 1656-1664DOI: (10.1016/j.joca.2016.04.017) Copyright © 2016 Osteoarthritis Research Society International Terms and Conditions