Digestive System: Outcome: I can describe different digestive hormones used in the chemical breakdown of food. Drill: Which digestive system disorder is the result of blockage of bile and damage to bile duct walls from gallstones?

Hormonal Regulation of Digestive Activities Five major hormones regulate digestive activities Four of them are produced by the duodenum Duodenum coordinates gastric activity and digestive secretion according to characteristics of the arriving chyme © 2015 Pearson Education, Inc.

Hormonal Regulation of Digestive Activities Five major hormones regulate digestive activities (continued) Gastrin Secreted in pylorus and into duodenum Stimulated by food presence in stomach and duodenum Particularly for high protein content Increases stomach mobility and production of gastric acids and enzymes Only hormone NOT produced in small intestine (duodenum) © 2015 Pearson Education, Inc.

Hormonal Regulation of Digestive Activities Five major hormones regulate digestive activities (continued) Secretin Released by duodenum upon arrival of chyme (food mixed with gastric acids and juices) Increases secretion of bile from liver and buffers from pancreas (increases pH of chyme) Also decreases gastric motility and secretory rates © 2015 Pearson Education, Inc.

Hormonal Regulation of Digestive Activities Five major hormones regulate digestive activities (continued) Gastric inhibitory peptide (GIP) Released by duodenum when fats and carbohydrates (especially glucose) enter small intestine Inhibits gastric activity Increases insulin release from pancreas © 2015 Pearson Education, Inc.

Hormonal Regulation of Digestive Activities Five major hormones regulate digestive activities (continued) Cholecystokinin (CCK) Secreted by duodenum when chyme arrives Especially when chyme contains lipids and partially digested proteins Increases enzyme production and secretion from pancreas Causes contraction of the gallbladder Ejecting bile into the duodenum © 2015 Pearson Education, Inc.

Hormonal Regulation of Digestive Activities Five major hormones regulate digestive activities (continued) 5. Vasoactive intestinal peptide (VIP) Released by duodenum Stimulates secretion of intestinal glands Dilates regional capillaries (to absorb more nutrients) Inhibits acid production in the stomach © 2015 Pearson Education, Inc.

Pattern of hormone release and effects of those hormones in the digestive system Slide 1 Ingested food Hormone Action Food in stomach KEY Inhibits Stimulates Acid production by parietal cells Facilitates Gastrin Stimulation of gastric motility; mixing waves increase in intensity Release of insulin from pancreas GIP Release of pancreatic enzymes and buffers Chyme in duodenum Secretin and CCK Bile secretion and ejection of bile from gallbladder Dilation of intestinal capillaries VIP Nutrient absorption NUTRIENT UTILIZATION BY ALL TISSUES Material arrives in jejunum © 2015 Pearson Education, Inc. Figure 22.14 2

You will be assigned one of these hormones: Based on your hormone, create a one-pager with illustrations and images discussing the source of the hormone, its functions, diseases and treatments related to the hormone, and other characteristics (at least 3) about it. This is to be done INDIVIDUALLY © 2015 Pearson Education, Inc.

1: Secretin 2: Cholecystokinin (CCK) 3: Vasoactive Intestinal Peptide (VIP) 4: Gastrin 5: Gastric Inhibitory Peptide (GIP) 6: Pick whichever you want © 2015 Pearson Education, Inc.

Digestive System: Exit Ticket: Which is the only digestive hormone NOT produced in the small intestine?