The temporal dynamics of switch between hippocampal attractor states Karel Jezek CBM, Trondheim Lab meeting, 13.October, 2008

how does the HP/EC system toggle between multiple spatial maps? hippocampal spatial representation is discontinuous and our perception of the surrounding world as well a basic need to flexibly update the orientation system whenever the sensory inputs do not match with the active representation how does the HP/EC system toggle between multiple spatial maps?

pretraining

pretraining

testing

testing TELEPORT TASK

example of recorded CA3 units population sleep A B

reference population vectors (expected activity) B A B

test population vectors fissure eeg 6-12 Hz

example of 20 sec. running in environments A and B

map overlap is expressed within single theta cycle P-correlation coeff. Cells 1...n fissure eeg 6-12 Hz seconds

Patterns of remapping - state alternation TELEPORTATION 24 sec. B A

Alternation between states correlation plots 3 8 Alternation between states correlation plots Animal running in env. A, transiently activating the representation for B each frame represents population activity within one theta cycle pink dot- animal’s current position 4 9 5 10 B A 1 6 11 2 7 12

Transitions between maps in the “teleportation” experiment (Jezek et al, 2011)

Towards episodic memory (De Lavilleon et al 2015)