? Glucose uptake, Storage, Lipogenesis

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Presentation transcript:

? Glucose uptake, Storage, Lipogenesis WHY? 16.08.jpg Glucose uptake, Storage, Lipogenesis The Integrator integrates multiple inputs

Another hormone that regulates plasma glucose concentration Glucagon prevails during post-absorptive phase 16.09.jpg Transition from absorptive to post-absorptive phase?

Fig. 16.10 EPI, yet another horomone in glucose homeostasis 16.10.jpg

Glucose-counterregulatory controls (oppose effects of insulin) Glucagon Epinephrine Cortisol (permissive effect) Growth hormone (permissive effect)

Who Cares?

A Case Study On our website at http://webs.wofford.edu/davisgr/bio342/oggt.htm

Oral Glucose Tolerance Test Overnight fast, no beverages other than water Fasting blood sample Ingest 75 grams glucose Blood samples every 0.5 hours for 3-5 hours Plot plasma glucose concentration over time Compare curves

Hypoglycemia 60

Stress, Emergency (fight or flight) Effect on Alpha Cells Effect on Beta cells

The Answer to the Problem? Rationale for substituting protein for carbohydrate midnight snack?

Acid Reflux (-) Proteins & amino acids in stomach (-) Enteroendocrine cells of stomach Gastrin HCl secretion by Parietal cells in stomach Hydrolysis of proteins