Clinical application Dx exercise intolerance 1.1  VO2max   VO2 AT

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Presentation transcript:

Clinical application Dx exercise intolerance 1.1  VO2max   VO2 AT 1.2 RER >1.2 (HRmax is not achieved) 1.3  breathing reserve < 20% (N=20-40%) 1.4  SaO2 1.5 VE/VO2 (ventilatory equivalent for oxygen) > 40 Dx exercise-induced bronchospasm (EIB) Aerobic fitness evaluation

Research study Optimal level of physical activity in children and adolescent with chronic lung disease

Objectives To study the optimal level of physical activity in children and adolescents with CLD

VO2 at AT  correlate with physical activity Experimental design Normal (n=18) CLD (n=18) Hx & PE VO2 at AT  correlate with physical activity PFT - Spirometry - Lung volumes - DLco Exercise stress test

Results Chronic lung diseases: - Chronic interstitial lung 1 - Post lobectomy 5 - Pulmonary hemosiderosis 1 - Fibrotic lung 3 - BPD 2 - Asthma moderate persistent 6

Abnormal PFT Obstructive lung 7 (FEV1 80.0 + 12.9%pred) Restrictive lung 7 (TLC 63.7 + 12.5%pred) Diffusion defect 1 (DLco/VA = 77 %pred) Hyperinflation 9 (RV/TLC 38.9 + 6.5%pred)

CLD (n = 18) Control P FVC 77.3 + 22.6 97.9 + 12.5 0.002 FEV1 74.3 + 17.6 104.0 + 12.6 < 0.001 FEV1/FVC 83.4 + 12.7 90.1 + 3.8 0.047 FEF25-75% 49.9 + 23.1 75.6 + 18.6 0.001 TLC 82.8 + 18.6 95.6 + 9.8 0.015 RV/TLC 30.8 + 10.2 24.4 + 5.9 0.027 DLco/VA 113.2 + 27.3 109.1 + 30.3 0.671