Volume 389, Issue 10071, Pages (February 2017)

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Volume 389, Issue 10071, Pages 815-822 (February 2017) Diagnostic accuracy of multi-parametric MRI and TRUS biopsy in prostate cancer (PROMIS): a paired validating confirmatory study  Hashim U Ahmed, FRCS, Ahmed El-Shater Bosaily, MBBCh, Louise C Brown, PhD, Rhian Gabe, PhD, Prof Richard Kaplan, FRCP, Prof Mahesh K Parmar, DPhil, Yolanda Collaco-Moraes, PhD, Katie Ward, BSc, Richard G Hindley, FRCS, Alex Freeman, FRCPath, Alex P Kirkham, FRCR, Robert Oldroyd, MA, Chris Parker, FRCR, Prof Mark Emberton, FRCS  The Lancet  Volume 389, Issue 10071, Pages 815-822 (February 2017) DOI: 10.1016/S0140-6736(16)32401-1 Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 1 Trial profile MP-MRI=multi-parametric MRI. CBP=combined biopsy procedure. The Lancet 2017 389, 815-822DOI: (10.1016/S0140-6736(16)32401-1) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 2 Diagnostic accuracy for detection of clinically significant cancer (primary definition) between MP-MRI and TPM-biopsy MP-MRI=multi-parametric MRI. TPM-biopsy=template prostate mapping biopsy. Pie charts represent actual MP-MRI scores 1–5. Sensitivity 93% (95% CI 88–96), positive predictive value 51% (46–56), specificity 41% (36–46), negative predictive value 89% (83–94). The Lancet 2017 389, 815-822DOI: (10.1016/S0140-6736(16)32401-1) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

Figure 3 Diagnostic accuracy for detection of clinically significant cancer (primary definition) between TRUS-biopsy and TPM-biopsy TRUS-biopsy=transrectal ultrasound-guided prostate biopsy. TPM-biopsy=template prostate mapping biopsy. Sensitivity 48% (95% CI 42–55), positive predictive value 90% (83–94), specificity 96% (94–98), negative predictive value 74% (69–78) The Lancet 2017 389, 815-822DOI: (10.1016/S0140-6736(16)32401-1) Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Terms and Conditions

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