Simon P. Dunlop, Nicholas S. Coleman, Elaine Blackshaw, Alan C

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Presentation transcript:

Abnormalities of 5-hydroxytryptamine metabolism in irritable bowel syndrome Simon P. Dunlop, Nicholas S. Coleman, Elaine Blackshaw, Alan C. Perkins, Gulzar Singh, Charles A. Marsden, Robin C. Spiller Clinical Gastroenterology and Hepatology Volume 3, Issue 4, Pages 349-357 (April 2005) DOI: 10.1016/S1542-3565(04)00726-8 Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 1 Colonic transit by radiopaque marker methods in PI-IBS and C-IBS patients vs. controls. Horizontal bar represents mean. Clinical Gastroenterology and Hepatology 2005 3, 349-357DOI: (10.1016/S1542-3565(04)00726-8) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 2 Postprandial release of 5-HT in PI-IBS and C-IBS patients vs. controls. Mean ± SEM error bars are shown. Clinical Gastroenterology and Hepatology 2005 3, 349-357DOI: (10.1016/S1542-3565(04)00726-8) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 3 AUC of 5-HT release for 3 hours after a test meal in PI-IBS and C-IBS patients vs. controls. Horizontal bar represents mean. Clinical Gastroenterology and Hepatology 2005 3, 349-357DOI: (10.1016/S1542-3565(04)00726-8) Copyright © 2005 American Gastroenterological Association Terms and Conditions

Figure 4 Peak 5-HT levels in platelet-poor plasma after a 522-kcal meal in PI-IBS and C-IBS patients vs. controls. Horizontal bar shows median. Clinical Gastroenterology and Hepatology 2005 3, 349-357DOI: (10.1016/S1542-3565(04)00726-8) Copyright © 2005 American Gastroenterological Association Terms and Conditions