Thrombin generation: biochemical possibilities and clinical reality

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Thrombin generation: biochemical possibilities and clinical reality by H. Coenraad Hemker Blood Volume 126(3):288-289 July 16, 2015 ©2015 by American Society of Hematology

The procoagulant network. The procoagulant network. Arrows indicate activations. The thicker arrows are operative at higher tissue factor concentrations. Red stars indicate activation by thrombin. The gray surface represents the platelet, and the light green surface represents tissue factor–containing membrane from wounded tissue, microparticles, or blood-borne tissue factor. VWF, von Willebrand factor. The dotted arrow denotes unconfirmed tissue factor–mediated activation of factor XI. H. Coenraad Hemker Blood 2015;126:288-289 ©2015 by American Society of Hematology