Further insights into the role of the annexin A5 M2 haplotype as recurrent pregnancy loss factor, assessing timing of miscarriage and partner risk Frank.

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Presentation transcript:

Further insights into the role of the annexin A5 M2 haplotype as recurrent pregnancy loss factor, assessing timing of miscarriage and partner risk Frank Tüttelmann, M.D., Petar Ivanov, M.D., Ph.D., Charlotte Dietzel, Anna Sofroniou, Tsvetomira M. Tsvyatkovska, Regina S. Komsa- Penkova, Ph.D., Arseni Markoff, Ph.D., Peter Wieacker, M.D., Nadja Bogdanova, M.D. Fertility and Sterility Volume 100, Issue 5, Pages 1321-1325 (November 2013) DOI: 10.1016/j.fertnstert.2013.06.046 Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Forrest plots showing odds ratios for M2 carriage in specific RPL groups compared with population controls. An enrichment of M2 carriers is evident in total patient samples (A, odds ratio, 1.6; 95% confidence interval, 1.2–2.1; P=.003) as well as in all subgroups (B, embryonal losses; C, early fetal losses; D, late fetal losses). The highest and significant increase was found for women with early fetal losses (C, odds ratio, 1.9; 95% confidence interval, 1.3–3.0; P=.003). Fertility and Sterility 2013 100, 1321-1325DOI: (10.1016/j.fertnstert.2013.06.046) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions