Quantitative analysis of the latent reservoir during treatment interruption. Quantitative analysis of the latent reservoir during treatment interruption.

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Quantitative analysis of the latent reservoir during treatment interruption. Quantitative analysis of the latent reservoir during treatment interruption. (A) Study design. Green arrows indicate combination bNAb infusion. Black arrows indicate the time points that were sampled. (B) NFL HIV-1 genome sequencing strategy (11). All viruses that had deletion in env were excluded from further analysis. (C) Comparison of reservoir measurements. Graph shows frequency per million CD4+ T cells at the preinfusion (wk-2) and week-12 (wk12) time points: gag+ proviruses (gag), env+ proviruses (env), near full-size proviruses (near full size) (Left), intact proviruses (intact) (Middle), and inducible proviruses (Q2VOA) (17) (Right). Each dot represents a different participant. Horizontal bars indicate median values. Statistical significance was determined using two-tailed Mann–Whitney U test. (D) Pearson correlation between frequency of intact proviruses and other reservoir measurements at the preinfusion (wk-2) (circles) and wk12 (triangles) time points. Participant 9254 was excluded from the quantitative analysis because of inadequate sample availability. Ching-Lan Lu et al. PNAS 2018;115:48:E11341-E11348 ©2018 by National Academy of Sciences