Effects of Radiation on the Embryo and Fetus

Slides:



Advertisements
Similar presentations
Radiation Long Term Effects II
Advertisements

Pregnancy and Medical Radiation
Better Safe Than Sorry: The Biological Basis of Fetal Alcohol Syndrome and other Alcohol-Related Birth Defects.
By. RADIATION & PREGNANCY Diagnostic & Therapeutic procedures causing exposure of the abdomen of women likely to be pregnant should be avoided unless.
Ninth lecture.
INTERNATIONAL COMMISSION ON RADIOLOGICAL PROTECTION —————————————————————————————————————— Pregnancy and Medical Radiation.
Radiation and Pregnancy ©Health Physics Society. Medical X-Ray Exams Radiation exposure that is extra- abdominal will not contribute significant radiation.
Chapter 3: Prenatal Development and Birth Teratogens: Hazardous to the Baby’s Health By Kati Tumaneng (for Drs. Cook & Cook)
Development Area vs. Approach Child Psychology Infancy Adolescence Adulthood Old Age Prenatal.
Pregnancy Module  Objectives  To understand the effects of radiation on the fetus in doses greater than 10 Rem.  To understand the reason for “Declaring.
Prenatal Development In which we examine the three stages of development from conception to birth, and the causes of congenital defects that can occur.
Birth Defects Dr Rania Gabr.
Chapter 4 Prenatal Development and Birth. Chapter 4- Prenatal Development Time of fastest development Conception –Ova (eggs) travels from ovary to uterus.
 Sexual intercourse- the reproductive process in which the penis is inserted into the vagina and through which a new human life nay begin.  Embryo-
Dose Response.
Nuclear Medicine. International Atomic Energy Agency Part 2: Radiation units and dose quantities Topic 1: Exposure and exposure rate.
Teratology Wendy Chung, MD PhD. Mrs. B 30 year old woman comes to you because her 20 week prenatal ultrasound showed a hole in the heart Patient and her.
Medical Aspects of Developmental Biology: Birth Defects, Endocrine Disruptors, & Cancer Lange BIOL 370 – Developmental Biology Topic #20.
Teratology Wendy Chung, MD PhD. Mrs. B 30 year old woman comes to you because her 20 week prenatal ultrasound showed a hole in the heart Patient and her.
IAEA International Atomic Energy Agency RADIATION PROTECTION IN DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY L14: Radiation exposure in pregnancy IAEA Training.
Copyright © 2010, Pearson Education Inc., All rights reserved.  Prepared by Katherine E. L. Norris, Ed.D.  West Chester University This multimedia product.
Avoiding Dangers to the Baby
A Healthy Pregnancy. Problems in Prenatal Development Prenatal development refers to the process in which a baby develops from a single cell after conception.
Radiation Effects Wilfrido Cordova. Causes due to Radiation  May injure embryonic cells, which would cause cell death  Can injure the chromosome  There.
Pregnancy and Drug Abuse Eva Janecek-Rucker. Learning Objectives 1.To develop a knowledge base of the effects of substances of abuse (e.g., alcohol, cocaine,
Ahmed Group Lecture 28 Effects of Radiation on the Embryo and Fetus Lecture 28.
Prenatal Development Information in this presentation is taken from UCCP Content.
Smoking in pregnancy 전임의 최은정. Introduction  In the US : about 16 % of pregnant women smoke  In Korea : 8-10%  Smoking during pregnancy in.
lec. 1 U/S Dr. Lina Hammad Level 9
Fetal death in pregnant diabetic women B-Khani Assistant professor of Isfahan University of Medical Science.
By: Fatima Grajeda Human Growth and Development.  Fertilization is when the egg and the sperm unite and this process starts at ovulation.
Prenatal and Neonatal. Prenatal Development Prenatal development lasts approximately 38 weeks from conception to birth. Three periods of development:
What Can adversely affect a pregnancy? Things that can harm the baby.
BIOLOGICAL EFFECTS OF IONIZING RADIATION
Radiation in pregnancy Kangnam CHA General Hospital Cho Yeonkyung.
Pregnancy and Childbirth Human Sexuality Workbook Ch. 5 Pg.63 Fertilization: the union of a single sperm and an ovum (egg).
Immunosuppressive drugs & treatment of HTN in pregnancy Nephrology dept. R2 우용식.
Management infant born with mother Chickenpox
PSYC 206 Lifespan Development Bilge Yagmurlu.
PSYC 206 Lifespan Development Bilge Yagmurlu.
The Life Cycle Your Life Began as a Single cell, smaller than this period at the end of this sentence . Now your body is made up of trillion of cells,
PSYC 206 Lifespan Development Bilge Yagmurlu.
Unit 9: Developmental Psychology
Vital statistics in obstetrics.
Congenital Toxoplasmosis
الاثنين 8/12/2013 Lec.4 أ.د.عبد الجبار الحبيطي
Chapter 4 Prenatal Development.
Prof. Alaa A. Elsisi,PhD.
Maternal & Perinatal Mortality
Facial Features of FAS.
Radiation Protection(1)
Congenital Anomalies and Teratogens
Psychology 235 Child Psychology Dr. Blakemore
Development in the Critical Period:
Better Safe Than Sorry: The Biological Basis of Fetal Alcohol Syndrome and other Alcohol-Related Birth Defects.
The Developing Person Through the Life Span, Ninth Edition by Kathleen Stassen Berger Clicker Question Presentation Slides Chapter 4 Critical Thinking.
Slides 8-14 of 34.
Chromosomal deletions.
Better Safe Than Sorry: PowerPoint Slides for Transparencies
RADIATION PROTECTION IN DIAGNOSTIC AND INTERVENTIONAL RADIOLOGY
Reproductive Health and Fluoroscopy
It’s been a long road…….. When will it end?.
Intra uterine fetal development
Embryology research. Researcher using forceps while preparing a specimen of a mouse embryo during research on the embryology of the heart. The mouse embryo.
DEFINITIONS : QUICK REVIEW
“Mkhitar Gosh” University, Armenia Medical biology courses : Lecture N 17 BASES OF ONTOGENESIS.
Developmental Psychology
RAD 315 RADIOBIOLOGY AND RADIATION PROTECTION
Presentation transcript:

Effects of Radiation on the Embryo and Fetus Lecture 28 Effects of Radiation on the Embryo and Fetus

Intrauterine death Congenital abnormalities and neonatal death Microcephaly, mental retardation Growth retardation Dose, dose rate, and stage in gestation Human experience of pregnant women exposed to therapeutic dose

Three important stages of development Pre-implantation Organogenesis Newly fertilized mouse egg Three important stages of development Pre-implantation Organogenesis Fetal development 3rd day –mouse embryo

Classic effects of radiation on Embryo and Fetus 1. Lethal effects pre-implantation death intra-uterine death neonatal death 2. Malformations Teratogenic effects 3. Growth disturbances Effects depend on: Dose, Stage of gestation and dose rate

Dose= 2 Gy

Intrauterine death Congenital abnormalities and neonatal death Microcephaly, mental retardation Growth retardation Dose, dose rate, and stage in gestation Human experience of pregnant women exposed to therapeutic dose

Congenital malformations (1 Gy)

Irradiation during the period of organogenesis Normal Resorbed fetuses

Irradiation during the period of organogenesis Eye defects

Intrauterine death Congenital abnormalities and neonatal death Microcephaly, mental retardation Growth retardation Dose, dose rate, and stage in gestation Human experience of pregnant women exposed to therapeutic dose

Experience in humans Medical exposures Atomic bomb survivors Effects: Microcephaly CNS defects Growth retardation For period 16-25 weeks Absorbed fetal dose (Rads)

Medical Radiation effects on Embryo and Fetus Less severe abnormalities in human embryo exposed before 2-3 weeks of gestation was observed, although an increase abortion was reported. Severe abnormalities observed between 4 and 11 weeks of gestation. Abnormalities involving eye, skeleton, genital organs and stunted growth, microcephaly and mental retardation was observed between 11 and 16 weeks of gestation. Weeks 16-20 showed mild stunted growth, microcephaly and mental retardation. Irradiation after 30 weeks caused functional disabilites.

Intrauterine death Congenital abnormalities and neonatal death Microcephaly, mental retardation Growth retardation Dose, dose rate, and stage in gestation Human experience of pregnant women exposed to therapeutic dose

Comparison of human and animal data