Drug-Induced Liver Injury: Morbidity, Mortality, and Hy’s Law

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Presentation transcript:

Drug-Induced Liver Injury: Morbidity, Mortality, and Hy’s Law Arie Regev Gastroenterology Volume 147, Issue 1, Pages 20-24 (July 2014) DOI: 10.1053/j.gastro.2014.05.027 Copyright © 2014 Terms and Conditions

Figure 1 eDISH, Evaluation of Drug-Induced Serious Hepatotoxicity. eDISH plot showing peak ALT and TBL levels from a database of a phase 3 clinical trial. Over representation of points on study drug in the Hy's Law range quadrant and the Temple's Corollary range quadrant suggests a possible increased risk of severe DILI. ALT, alanine aminotransferase; TBL, total bilirubin; ULRR, upper limit of reference range. Gastroenterology 2014 147, 20-24DOI: (10.1053/j.gastro.2014.05.027) Copyright © 2014 Terms and Conditions