Diverticular Disease–Associated Segmental Colitis Laura W. Lamps, Whitfield L. Knapple  Clinical Gastroenterology and Hepatology  Volume 5, Issue 1, Pages 27-31 (January 2007) DOI: 10.1016/j.cgh.2006.10.024 Copyright © 2007 AGA Institute Terms and Conditions

Figure 1 Cryptitis, crypt abscesses, and expansion of the lamina propria by a mononuclear cell infiltrate (hematoxylin-eosin; original magnification 100 ×). Clinical Gastroenterology and Hepatology 2007 5, 27-31DOI: (10.1016/j.cgh.2006.10.024) Copyright © 2007 AGA Institute Terms and Conditions

Figure 2 Prominent basal lymphoid aggregates are virtually always present in diverticular disease–associated segmental colitis (hematoxylin-eosin; original magnification 100 ×). Clinical Gastroenterology and Hepatology 2007 5, 27-31DOI: (10.1016/j.cgh.2006.10.024) Copyright © 2007 AGA Institute Terms and Conditions

Figure 3 Expansion of the lamina propria by a mononuclear cell infiltrate and architectural distortion in a biopsy specimen (hematoxylin-eosin; original magnification 100 ×). Clinical Gastroenterology and Hepatology 2007 5, 27-31DOI: (10.1016/j.cgh.2006.10.024) Copyright © 2007 AGA Institute Terms and Conditions

Figure 4 Basal lymphoplasmacytosis and Paneth cell metaplasia are frequently present in diverticular disease–associated segmental colitis, mimicking ulcerative colitis (hematoxylin-eosin; original magnification 200 ×). Clinical Gastroenterology and Hepatology 2007 5, 27-31DOI: (10.1016/j.cgh.2006.10.024) Copyright © 2007 AGA Institute Terms and Conditions

Figure 5 Sections show cryptitis, crypt abscesses, basal lymphoplasmacytosis, and architectural distortion in this resection specimen from a patient with diverticular disease–related segmental colitis. Note that the inflammatory process is confined to the mucosa (hematoxylin-eosin; original magnification 200 ×). Clinical Gastroenterology and Hepatology 2007 5, 27-31DOI: (10.1016/j.cgh.2006.10.024) Copyright © 2007 AGA Institute Terms and Conditions

Figure 6 Cryptitis and marked architectural distortion in a colon biopsy from a patient with culture-proven Salmonella infection (hematoxylin-eosin; original magnification 200 ×). Clinical Gastroenterology and Hepatology 2007 5, 27-31DOI: (10.1016/j.cgh.2006.10.024) Copyright © 2007 AGA Institute Terms and Conditions

Figure 7 Patchy acute inflammation, crypt abscess formation, and reactive epithelial changes in a biopsy specimen from a patient with NSAID-associated colitis (hematoxylin-eosin; original magnification 100 ×). Clinical Gastroenterology and Hepatology 2007 5, 27-31DOI: (10.1016/j.cgh.2006.10.024) Copyright © 2007 AGA Institute Terms and Conditions

Figure 8 Focal epithelial disarray, cryptitis, and prominent lymphoid aggregates in diversion colitis. (A) original magnification ×20; (B) original magnification 200 ×. Clinical Gastroenterology and Hepatology 2007 5, 27-31DOI: (10.1016/j.cgh.2006.10.024) Copyright © 2007 AGA Institute Terms and Conditions