A20 (TNFAIP3) genetic alterations in EBV-associated AIDS-related lymphoma by Lisa Giulino, Susan Mathew, Gianna Ballon, Amy Chadburn, Sharon Barouk, Giuseppina.

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A20 (TNFAIP3) genetic alterations in EBV-associated AIDS-related lymphoma by Lisa Giulino, Susan Mathew, Gianna Ballon, Amy Chadburn, Sharon Barouk, Giuseppina Antonicelli, Lorenzo Leoncini, Yi Fang Liu, Swarna Gogineni, Wayne Tam, and Ethel Cesarman Blood Volume 117(18):4852-4854 May 5, 2011 ©2011 by American Society of Hematology

ARL Tumor characterization. ARL Tumor characterization. (A) Distribution of tumor type is shown. Cases included DLBCL of the GCB (n = 21) and non-GCB (n = 14) subtypes, Burkitt lymphoma (n = 8), plasmablastic lymphoma (n = 5), B-cell lymphoma, unclassifiable (BCL, U; n = 7), and polymorphic lymphoproliferative disease (LPD; n = 1). EBV positivity shown was determined by EBER in situ hybridization. (B) LMP-1 expression as determined by immunohistochemistry. Fifty cases lacked LMP-1 in all tumor cells (left). Two cases showed LMP-1 expression in < 10% of tumor cells (middle). A tumor cell expressing LMP-1 is indicated by a black arrow, and representative tumor cells lacking LMP-1 are indicated by red arrows. Four cases expressed LMP-1 in > 90% of tumor cells (right). Original magnification ×600 with 60×/0.80 objective lens. Microscope: Olympus BX 41; camera: Olympus Q-COLOR3; software: QCapture, Version 2.9.8.0 (Quantitative Imaging Corporation). Lisa Giulino et al. Blood 2011;117:4852-4854 ©2011 by American Society of Hematology

A20 Alterations in ARL. (A) Dual-color FISH analysis of tumor samples hybridized with A20 probe (green) and chromosome 6 centromeric probe (red). A20 Alterations in ARL. (A) Dual-color FISH analysis of tumor samples hybridized with A20 probe (green) and chromosome 6 centromeric probe (red). Top case shows wild-type A20. A20 heterozygous loss was shown in 5 cases (bottom left). One case was found to have A20 homozygous loss (bottom right). Magnification: Apochromatic 100× lens with 1.4 aperture; microscope: Nikon Eclipse 80i; camera: Jai CV-A10CL; software: Cytovision Imaging Software (Genetix Corp). (B) Representative chromatogram of normal DNA and tumor sample with A20 nonsense mutation in exon 2. This case had A20 monoallelic deletion, shown by FISH. The normal nucleotide peak in the mutated tumor sample probably represents infiltrating inflammatory cells. Software used was 4Peaks Version 1.7.2. (C) A20 Immunohistochemistry showing tumor cases with presence of A20 (left) and absence of A20 (right). Original magnification ×600 with 60×/0.80 objective lens. Microscope: Olympus BX 41; camera: Olympus Q-COLOR3; software: QCapture, Version 2.9.8.0 (Quantitative Imaging Corporation). (D) Incidence of A20 alteration is shown. (E) Incidence of A20 alteration in LMP-1 positive (+), negative (−), and intermediate (+/−) samples. Lisa Giulino et al. Blood 2011;117:4852-4854 ©2011 by American Society of Hematology