Klotho reduction increases the expression of cytokine response factors in the CP. (A–C) ICAM1 (A and B) and IRF7 (C) immunoreactivity in the CP of 19-

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Sophie Croizier, Vincent Prevot, Sebastien G. Bouret Cell Reports

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Klotho reduction increases the expression of cytokine response factors in the CP. (A–C) ICAM1 (A and B) and IRF7 (C) immunoreactivity in the CP of 19- to 22-mo-old WT vs. Klotho reduction increases the expression of cytokine response factors in the CP. (A–C) ICAM1 (A and B) and IRF7 (C) immunoreactivity in the CP of 19- to 22-mo-old WT vs. Klothoflox/flox (Flox) mice measured 9 mo after Cre injection. n = 5 to 7 mice per group. Sections of CP from the lateral ventricle (A–C) or fourth ventricle (C, Rightmost images) were colabeled for cytokeratin (gray), klotho (green), and ICAM1 (red) (A) or klotho (green) and IRF7 (red) (C). (Scale bars: 100 µm.) The percent of the cytokeratin-immunoreactive area that was also positive for ICAM1 was quantitated in B. (D and E) High magnification confocal images of the CP labeled for ICAM1 (red) and transthyretin (green) (D) or AQP1 (green) (E). [Scale bars: 25 µm (D), 50 µm (E).] ***P < 0.001 by unpaired, two-tailed t test. Values in bar graphs are means ± SEM. Lei Zhu et al. PNAS 2018;115:48:E11388-E11396 ©2018 by National Academy of Sciences