Circulating biochemical markers of bone remodeling in uremic patients

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Circulating biochemical markers of bone remodeling in uremic patients Pablo Ureña, Marie-Christine de Vernejoul Kidney International Volume 55, Issue 6, Pages 2141-2156 (June 1999) DOI: 10.1046/j.1523-1755.1999.00461.x Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 1 Relationship between plasma intact parathyroid hormone (IPTH) and bone-specific alkaline phosphatase (bAP) in 142 adult hemodialysis patients. Plasma IPTH was measured using a radioimmunometric assay for intact human PTH 1-84 (Allegro Intact PTH; Nichols Institute, San Juan Capistrano, CA, USA). The range of normal values was between 10 and 70pg/ml. Plasma bAP was measured using the radioimmunometric assay Tandem-R (Ostase, Hybritech Europe S.A., Belgium). The mean ± sd value obtained in normal adult individuals was 11.8 ± 4.3ng/ml (normal range 7.5 to 16.0ng/ml). Dashed lines indicate lower and upper limits for bAP levels and upper limits for IPTH values (r = 0.559; N = 142; P < 0.001). Kidney International 1999 55, 2141-2156DOI: (10.1046/j.1523-1755.1999.00461.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 2 Schematic representation of a type I procollagen molecule. It illustrates the regions recognized by the antibodies used to measure the C-terminal end of type I procollagen (PICP) and the C-terminal type I procollagen telopeptide (ICTP). Kidney International 1999 55, 2141-2156DOI: (10.1046/j.1523-1755.1999.00461.x) Copyright © 1999 International Society of Nephrology Terms and Conditions

Figure 3 Schematic representation of two major collagen cross-linking molecules pyridinoline (PYD) and deoxypyridinoline (DPD). AA means the amino acid number at which PYD molecule attaches to amino- and carboxy-terminal ends of type I collagen molecules. Kidney International 1999 55, 2141-2156DOI: (10.1046/j.1523-1755.1999.00461.x) Copyright © 1999 International Society of Nephrology Terms and Conditions