Haemophilus influenzae Hap adhesin.

Slides:

Advertisements

Similar presentations

CD40L concentration-dependently binds to Mac-1's I-domain. Wolf D et al. Circulation Research 2011;109: Copyright © American Heart Association.

Advertisements

SIGNALING FROM THE CELL SURFACE TO THE NUCLEUS

The ECM, Cell Adhesion, and Integrins 2/12/15 Lecture 6, ChE

by Kevin J. Paavola, Harwin Sidik, J

Vaccines development of Vibrio vulnificus

Bacterial protein secretion systems

Methods by which pathogens cause disease: Adhesion: bacteria must bind to the cell surfaces Colonization: bacteria produce proteins and colonize parts.

Bacterial Protein Translocation & Pathogenesis

Pathogenesis of Infectious Diseases

y sus aplicaciones ambientales

From: Reengineering Human Bruch's Membrane Increases Rod Outer Segment Phagocytosis by Human Retinal Pigment Epithelium Trans. Vis. Sci. Tech ;4(5):10.

The ECM, Cell Adhesion, and Integrins

Validating Cdk‐dependent chromatin association changes of selected outliers A–EValidation of changes in chromatin affinity following Cdk inhibition of.

Prolyl‐hydroxylase‐domain proteins regulate hypoxia inducible factor‐α in response to O2 availability. Prolyl‐hydroxylase‐domain proteins regulate hypoxia.

Statistical analysis of transgene expression in pigs generated by lentiviral gene transfer. Statistical analysis of transgene expression in pigs generated.

Positioning of the TGF‐β3 and BMP receptor complexes on a membrane surface. Positioning of the TGF‐β3 and BMP receptor complexes on a membrane surface.

An overview of bacterial mechanisms for pathogenicity.

Surface distribution of immunogold‐labelled PS I (A–C) and ATP synthase (D–F) complexes. Surface distribution of immunogold‐labelled PS I (A–C) and ATP.

DNA‐anchored LacI–CFP–Luciferase aggregates capture misfolded cytosolic proteins. DNA‐anchored LacI–CFP–Luciferase aggregates capture misfolded cytosolic.

(A, B) Stereoscopic views of the P3 RNase MRP RNA domain in complex with the RNase MRP/RNase P protein components Pop6 and Pop7. (A, B) Stereoscopic views.

Yeast Tgl3p expressed in HeLa cells localizes to lipid droplets.

Face‐to‐face kinase domain dimerisation of human Ire1α.

Figure 1 Mechanism of thrombus formation during ST-segment

There are numerous hypothesized mechanisms by which cells might sense an electrical field. There are numerous hypothesized mechanisms by which cells might.

HCV NS5A Inhibitors: The Devil Is in the Details

Intestinal epithelial cells in microbial homeostasis.

Activity flow of the mTOR signaling network.

Microbial Influences in Inflammatory Bowel Diseases

Multiple sequence alignment of the BAR domains from Amphiphysins and from the subset of BAR domain family members that were shown to bind to a small GTPase.

Structure of the mouse stomatin domain.

Structure‐based functional characterization of H

Figure 1 Intrathymic T-cell differentiation

Immunosensory detection of intestinal bacteria.

PolyQ‐huntingtin promotes membrane ErbB2/HER2 accumulation and sustained signalling.A.Immunostaining of sections from MMTV‐PyVT/HdhQ7/Q7 (HdhQ7/Q7) and.

A Greasy Foothold for Helicobacter pylori

Clinical testing of calcineurin inhibitors cyclosporine A and tacrolimus in autoimmune disorders Clinical testing of calcineurin inhibitors cyclosporine.

Pharmacological analysis of Aβ degradation activity in the conditioned medium of astrocytoma cell lines Pharmacological analysis of Aβ degradation activity.

The production of reduced or oxidized glutathione can occur at various stages during the formation of native disulphide bonds. The production of reduced.

Andrey S. Shaw, Michael L. Dustin Immunity

Pan2 exploits the asymmetry and forms an extensive interface with the Pan3 dimerStructural details of the complex of ctPan3 PKC bound to the Pan3 interacting.

Usp5 sensitivity of S65 ubiquitin mutant chains Structure of ubiquitin in complex with Usp5 (PDB ID: 3IHP). Usp5 sensitivity of S65 ubiquitin mutant chains.

Oxidative Modification of Leukocyte Adhesion

Allosteric Activation of a Bacterial Stress Sensor

Anti-inflammatory Agents: Present and Future

Architecture of the chloroplast 70S ribosome

Helicobacter pylori in Health and Disease

The ER is the main source of cholesterol accumulated by STARD3 in endosomes The ER is the main source of cholesterol accumulated by STARD3 in endosomes.

Chemical inhibitors of microtubule function attenuate signal but do not affect pathway variability Chemical inhibitors of microtubule function attenuate.

Overview of structural and functional mechanisms by which enterovirulent bacteria cause diarrhea. Overview of structural and functional mechanisms by which.

Inhibition of NAMPT using the potent inhibitor FK866 sensitizes additional tumour cells to olaparib.A‐E.Sensitivity of the cell lines MDAMB468 (A), SUM149.

A and b) Moraxella catarrhalis ubiquitous surface protein (Usp) A2 binds collagen with high affinity. a and b) Moraxella catarrhalis ubiquitous surface.

MET inhibition promotes p21 nuclear translocation

Pt‐GG adducts in the active sites of Dpo4 and ypolη.

Revealing the Achilles Heel of Bacterial Toxins

CD44 binding surface of the Tiam2 PHCCEx domain.

Qiuhe Lu, Shan Li, Feng Shao Trends in Microbiology

WES identification of heterozygous compound mutations in ALPI

C266S laforin's effect on LD‐associated general defect in autophagy

Stop and Go Traffic to Tune T Cell Responses

Palbociclib increases proteasome activity and the clearance of protein aggregates without significant effects on autophagy Palbociclib increases proteasome.

WES identification of heterozygous compound mutations in ALPI

P2Y1 receptor mediated the directional migration of SVZ neuroblasts in an EF. (A) Suramin (general purinergic receptor inhibitor, 5 μM) did not affect.

NFAT Signaling Cell Volume 109, Issue 2, Pages S67-S79 (April 2002)

Nilotinib inhibits DDR1 invasive activity of patient‐derived CRC cells

Characterization of GDF11 signalling through type I and type II receptors. Characterization of GDF11 signalling through type I and type II receptors. Gene.

Disruption of integrin α8 signalling inhibits Fn1‐mediated metalloproteinase activation and augments the rate of prion replication ASchematic representation.

The Importance of Being Cleaved

General structure of RIFINs and STEVORs

Summary of bead tubulogenesis assay.

Events modulating E. coli colonization and fitness in the intestine.

Presentation transcript:

Haemophilus influenzae Hap adhesin. Haemophilus influenzae Hap adhesin. (A) Domain arrangement of Hap adhesin. Similar to other autotransporters, Hap contains three general domains: a signal peptide (SP), a passenger domain (HapS), and an outer membrane translocator domain (Hapβ). (B) Hap‐mediated Haemophilus influenzae pathogenesis. Red oval for bacterium and blue stick for Hap adhesin. The SAAT domain in the passenger domain mediates adherence to epithelial cells, invasion of epithelial cells, and bacterial aggregation. The ECM‐binding domain mediates adherence to fibronectin, laminin, and collagen IV. A host protein known as secretory leukocyte protease inhibitor (SLPI) inhibits Hap intermolecular autoproteolysis through its N‐terminal serine protease domain and results in accumulation of HapS on the bacterial surface, resulting in enhanced bacterial adhesive activity and microcolony formation (Hendrixson and St Geme, 1998). Guoyu Meng et al. EMBO J. 2011;30:3864-3874 © as stated in the article, figure or figure legend