Recombinant activated factor VII and prothrombin complex concentrates have different effects on bleeding and arterial thrombosis in the haemodiluted rabbit

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Presentation transcript:

Recombinant activated factor VII and prothrombin complex concentrates have different effects on bleeding and arterial thrombosis in the haemodiluted rabbit F. Le Saché, B. Le Bonniec, P. Gaussem, B. Dizier, M. Tagzirt, A. Godier, J. Emmerich, C.-M. Samama British Journal of Anaesthesia Volume 108, Issue 4, Pages 586-593 (April 2012) DOI: 10.1093/bja/aer450 Copyright © 2012 The Author(s) Terms and Conditions

Fig 1 Study protocol. VT, Tidal volume; IBT, ear immersion bleeding time; TA, thrombin activity; aPTT, activated partial thromboplastin time; P1, period 1; P2, period 2; P3, period 3. British Journal of Anaesthesia 2012 108, 586-593DOI: (10.1093/bja/aer450) Copyright © 2012 The Author(s) Terms and Conditions

Fig 2 Study randomization: P1, period 1; P2, period 2; P3, period 3. Treatment: PCC, prothrombin complex concentrates (40 IU FX kg−1); rFVIIa, recombinant activated factor VII (160 µg kg−1) or placebo (saline). British Journal of Anaesthesia 2012 108, 586-593DOI: (10.1093/bja/aer450) Copyright © 2012 The Author(s) Terms and Conditions

Fig 3 HS blood loss considering each group: PCC, prothrombin complex concentrates (40 IU FX kg−1); rFVIIa, recombinant activated factor VII (160 µg kg−1); placebo (saline); control (no haemodilution). Kruskal–Wallis’ test (P<0.05). British Journal of Anaesthesia 2012 108, 586-593DOI: (10.1093/bja/aer450) Copyright © 2012 The Author(s) Terms and Conditions

Fig 4 Progress of thrombin activity after injection of: (a) rFVIIa 160 µg kg−1; (b) PCC 40 IU FX kg−1; and (c) placebo. Bars are mean (sd). HD, haemodilution. British Journal of Anaesthesia 2012 108, 586-593DOI: (10.1093/bja/aer450) Copyright © 2012 The Author(s) Terms and Conditions