Association between domestic water hardness, chlorine, and atopic dermatitis risk in early life: A population-based cross-sectional study Michael R.

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Presentation transcript:

Association between domestic water hardness, chlorine, and atopic dermatitis risk in early life: A population-based cross-sectional study Michael R. Perkin, PhD, Joanna Craven, MPH, Kirsty Logan, PhD, David Strachan, MD, Tom Marrs, BM BS, Suzana Radulovic, MD, Linda E. Campbell, BSc, Stephanie F. MacCallum, MSc, W.H. Irwin McLean, DSc, Gideon Lack, MD, Carsten Flohr, PhD Louise Young, Victoria Offord, Mary DeSousa, Jason Cullen, Katherine Taylor, Anna Tseng, Bunmi Raji, Sarah Nesbeth, Gillian Regis, Charlie Bigwood, Charlotte Stedman, Sharon Tonner, Emily Banks, Yasmin Kahnum, Rachel Babic, Ben Stockwell, Erin Thompson, Lorna Wheatley, Devi Patkunam, Kerry Richards, Ewa Pietraszewicz, Alick Stephens, Asha Sudra, Victor Turcanu Michael R. Perkin, PhD, Joanna Craven, MPH, Kirsty Logan, PhD, David Strachan, MD, Tom Marrs, BM BS, Suzana Radulovic, MD, Linda E. Campbell, BSc, Stephanie F. MacCallum, MSc, W.H. Irwin McLean, DSc, Gideon Lack, MD, Carsten Flohr, PhD Louise Young, Victoria Offord, Mary DeSousa, Jason Cullen, Katherine Taylor, Anna Tseng, Bunmi Raji, Sarah Nesbeth, Gillian Regis, Charlie Bigwood, Charlotte Stedman, Sharon Tonner, Emily Banks, Yasmin Kahnum, Rachel Babic, Ben Stockwell, Erin Thompson, Lorna Wheatley, Devi Patkunam, Kerry Richards, Ewa Pietraszewicz, Alick Stephens, Asha Sudra, Victor Turcanu Journal of Allergy and Clinical Immunology Volume 138, Issue 2, Pages 509-516 (August 2016) DOI: 10.1016/j.jaci.2016.03.031 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Relationship between water total and free chlorine levels and CaCO3 content. Journal of Allergy and Clinical Immunology 2016 138, 509-516DOI: (10.1016/j.jaci.2016.03.031) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Relationship between total chlorine and free chlorine levels. Journal of Allergy and Clinical Immunology 2016 138, 509-516DOI: (10.1016/j.jaci.2016.03.031) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Geographic distribution of high/low CaCO3 and total chlorine levels for all EAT study participants. Each dot represents a participating child's home location. Journal of Allergy and Clinical Immunology 2016 138, 509-516DOI: (10.1016/j.jaci.2016.03.031) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Relationship between TEWL at 3 months of age and water hardness by filaggrin status for those with and without AD. Journal of Allergy and Clinical Immunology 2016 138, 509-516DOI: (10.1016/j.jaci.2016.03.031) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 5 The influence of water content on TEWL and AD prevalence by filaggrin status. A, Navy bars represent those with AD (categories 1 and 2 combined in Table IV). Orange bars represent infants with increased TEWL but no AD (category 3 in Table IV). B, The same data as Fig 5, A, are shown, but the AD category is divided into those with increased TEWL (category 2 in Table IV, navy with orange border) and those with normal TEWL (category 1 in Table IV, navy). In each column among those with increased TEWL (category 3 in Table IV, orange; category 2 in Table IV, navy with orange border), the percentage with AD (category 2 in Table IV, navy with orange border) is presented. Journal of Allergy and Clinical Immunology 2016 138, 509-516DOI: (10.1016/j.jaci.2016.03.031) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions