Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood Zaraquiza Zolkipli, MSc,

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Presentation transcript:

Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood Zaraquiza Zolkipli, MSc, Graham Roberts, DM, Victoria Cornelius, PhD, Bernie Clayton, RN, Sarah Pearson, RN, Louise Michaelis, MSc, Ratko Djukanovic, DM, Ramesh Kurukulaaratchy, DM, S. Hasan Arshad, DM Journal of Allergy and Clinical Immunology Volume 136, Issue 6, Pages 1541-1547.e11 (December 2015) DOI: 10.1016/j.jaci.2015.04.045 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Flow diagram of the study process. FU, Follow-up; ITT, intention to treat; OIT, oral immunotherapy. Journal of Allergy and Clinical Immunology 2015 136, 1541-1547.e11DOI: (10.1016/j.jaci.2015.04.045) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Cumulative sensitization to any common allergen (A) and HDM sensitization (B). OIT, Oral immunotherapy. Journal of Allergy and Clinical Immunology 2015 136, 1541-1547.e11DOI: (10.1016/j.jaci.2015.04.045) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Overview of study design. OIT, Oral immunotherapy. Journal of Allergy and Clinical Immunology 2015 136, 1541-1547.e11DOI: (10.1016/j.jaci.2015.04.045) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Cumulative proportion with eczema for all participants (A) and excluding those with eczema at baseline (B). OIT, Oral immunotherapy. Journal of Allergy and Clinical Immunology 2015 136, 1541-1547.e11DOI: (10.1016/j.jaci.2015.04.045) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E3 Cumulative proportion with reported wheeze symptoms for all participants (A) and excluding those with wheeze at baseline (B). OIT, Oral immunotherapy. Journal of Allergy and Clinical Immunology 2015 136, 1541-1547.e11DOI: (10.1016/j.jaci.2015.04.045) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E4 Cumulative proportion with food allergy. OIT, Oral immunotherapy. Journal of Allergy and Clinical Immunology 2015 136, 1541-1547.e11DOI: (10.1016/j.jaci.2015.04.045) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions