SCFAs Take a Toll En Route to Metabolic Syndrome

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SCFAs Take a Toll En Route to Metabolic Syndrome André Marette, Christian Jobin Cell Metabolism Volume 22, Issue 6, Pages 954-956 (December 2015) DOI: 10.1016/j.cmet.2015.11.006 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Gut Microbiota-Derived SCFAs Drives Hepatic Lipogenesis and Metabolic Syndrome in T5KO Mice Toll-like receptor 5-deficient (T5KO) mice displayed sub-chronic inflammation, which promotes intestinal microbial dysbiosis with concomitant increased SCFA-receptor expression and portal SCFA levels. Microbial-derived SCFAs contribute to insulin resistance and development of metabolic syndrome through augmented stearoyl CoA desaturase-1 (SCD1)-dependent conversion of lipotoxic saturated fatty acids (C16:0-C18:0) to steatotic C18:1 (oleate). Cell Metabolism 2015 22, 954-956DOI: (10.1016/j.cmet.2015.11.006) Copyright © 2015 Elsevier Inc. Terms and Conditions