Stephen J. Fowler, MD, Gaël Tavernier, PhD, Robert Niven, MD

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Presentation transcript:

High blood eosinophil counts predict sputum eosinophilia in patients with severe asthma Stephen J. Fowler, MD, Gaël Tavernier, PhD, Robert Niven, MD Journal of Allergy and Clinical Immunology Volume 135, Issue 3, Pages 822-824.e2 (March 2015) DOI: 10.1016/j.jaci.2014.09.034 Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Scatter plot of blood eosinophils (× 109 cells/L) against sputum eosinophils (as a percentage), with cutoffs shown for sputum eosinophilia of 2% or greater (dashed line) and blood eosinophil counts of 0.15 × 109 cells/L or greater (dotted line), 0.3 × 109 cells/L or greater (dashed line), and greater than 0.45 × 109 cells/L (solid line). Open circles represent samples from patients receiving moderate-dose steroids, and solid circles represent samples from those receiving high-dose steroids (≥10 mg/d prednisolone, 80 mg of intramuscular triamcinolone within the previous month, or ≥2000 μg/d beclomethasone or equivalent). Journal of Allergy and Clinical Immunology 2015 135, 822-824.e2DOI: (10.1016/j.jaci.2014.09.034) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Receiver operating characteristic curve for use of blood eosinophil counts to predict sputum eosinophil values of at least 2%. The area under the receiver operating characteristic curve was 0.79 (95% CI, 0.72-0.86; P < .001). Journal of Allergy and Clinical Immunology 2015 135, 822-824.e2DOI: (10.1016/j.jaci.2014.09.034) Copyright © 2014 American Academy of Allergy, Asthma & Immunology Terms and Conditions