Non-destructive evaluation of articular cartilage defects using near-infrared (NIR) spectroscopy in osteoarthritic rat models and its direct relation.

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Non-destructive evaluation of articular cartilage defects using near-infrared (NIR) spectroscopy in osteoarthritic rat models and its direct relation to Mankin score I. Afara, I. Prasadam, R. Crawford, Y. Xiao, A. Oloyede Osteoarthritis and Cartilage Volume 20, Issue 11, Pages 1367-1373 (November 2012) DOI: 10.1016/j.joca.2012.07.007 Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 (a) Experimental setup for near-infrared spectral data acquisition, (b) typical spectra of osteoarthritic models tested. Osteoarthritis and Cartilage 2012 20, 1367-1373DOI: (10.1016/j.joca.2012.07.007) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Characterization of OA changes in the animal models. (a) Representative macroscopic appearances of the tibial condyles at 8 weeks in sham and in three different OA models, where L stands for lateral compartment, and M for medial compartment. (b) Representative histology sections of tibial condyles at 8 weeks in sham and in three different OA models. Distal tibia was sectioned coronally and stained with Safranin-O. The most degenerated area (medial part) of each sample is included. Scale bar = 200 μm. ACLT = anterior cruciate ligament transaction induced OA model, MNX = menisectomy induced OA model and MIA = mono-ido-acetate chemical induced OA model. (c) Quantitation of Safranin-O stained sections using the Mankin histopathology scoring system. Values are the geometric mean ± 95% confidence interval (CI), *P = 0.0041 is considered significant. (d) Cartilage thickness measurements in sham and in three different animal models at week 8 were performed as described in the methodology. Values are the geometric mean ± 95% confidence interval (CI), *P < 0.001 (10 knees). Osteoarthritis and Cartilage 2012 20, 1367-1373DOI: (10.1016/j.joca.2012.07.007) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Score plot of the first and second principal components of (first derivative + SNV) preprocessed NIR spectral data showing classification of the osteoarthritic cartilage models into distinct groups (n = 36). Osteoarthritis and Cartilage 2012 20, 1367-1373DOI: (10.1016/j.joca.2012.07.007) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Relationship between NIR spectra and the structural integrity of the osteoarthritic cartilage models tested based on the Mankin score, (a) Calibration, and (b) Validation. Osteoarthritis and Cartilage 2012 20, 1367-1373DOI: (10.1016/j.joca.2012.07.007) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Correlation between NIR spectral data and the thickness of non-calcified cartilage from the osteoarthritic models, (a) Calibration, and (b) Validation. Thickness values from the tibia plateau were used here. Osteoarthritis and Cartilage 2012 20, 1367-1373DOI: (10.1016/j.joca.2012.07.007) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions