Randomized trial of near-infrared spectroscopy for personalized optimization of cerebral tissue oxygenation during cardiac surgery C.A. Rogers, S. Stoica,

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Randomized trial of near-infrared spectroscopy for personalized optimization of cerebral tissue oxygenation during cardiac surgery C.A. Rogers, S. Stoica, L. Ellis, E.A. Stokes, S. Wordsworth, L. Dabner, G. Clayton, R. Downes, E. Nicholson, S. Bennett, G.D. Angelini, B.C. Reeves, G.J. Murphy British Journal of Anaesthesia Volume 119, Issue 3, Pages 384-393 (September 2017) DOI: 10.1093/bja/aex182 Copyright © 2017 The Author(s) Terms and Conditions

Fig 1 Flow of participants showing eligibility, recruitment, protocol deviations, withdrawals, and loss to follow-up in the PASPORT trial. MMSE, mini mental state examination. British Journal of Anaesthesia 2017 119, 384-393DOI: (10.1093/bja/aex182) Copyright © 2017 The Author(s) Terms and Conditions

Fig 2 (A) Percentage of participants receiving RBC transfusions by group. (B) Cerebral oxygenation during the operative period expressed as mean NIRS area under the curve. (C) Mean oxygen delivery during CPB. (D) Oxygen utilization during CPB. Data are expressed as means (SD). CPB, cardiopulmonary bypass; NIRS, near-infrared spectroscopy; RBC, red blood cell. British Journal of Anaesthesia 2017 119, 384-393DOI: (10.1093/bja/aex182) Copyright © 2017 The Author(s) Terms and Conditions

Fig 3 Serum biomarkers of inflammation and brain and kidney injury. (A) S100B, a marker of brain injury. (B) Serum IL-6, a marker of systemic inflammation. (C,D) Serum creatinine (C) and urinary NGAL (D), biomarkers of kidney injury. Data are presented as means (SD). ICU, intensive care unit; IL, interleukin; IQR, interquartile range; NGAL, neutrophil gelatinase-associated lipocalcin. British Journal of Anaesthesia 2017 119, 384-393DOI: (10.1093/bja/aex182) Copyright © 2017 The Author(s) Terms and Conditions