Summary of fusion event frequency for wild-type (wt) and Cav1 Summary of fusion event frequency for wild-type (wt) and Cav1.3-ko IHCs. (A) Plot of event frequency for wild-type (n = 8 at rest, and n = 7 depolarized) and Cav1.3-ko IHCs at different Vm (n = 5). Summary of fusion event frequency for wild-type (wt) and Cav1.3-ko IHCs. (A) Plot of event frequency for wild-type (n = 8 at rest, and n = 7 depolarized) and Cav1.3-ko IHCs at different Vm (n = 5). (B) Normalized ICa for wild-type and Cav1.3-ko IHCs taken from Brandt et al. (32). Black asterisks indicate statistical comparison between wild type at rest (Vm: −75 mV) versus at depolarized Vm values, and red asterisks compare wild type and ko at the same Vm (*P < 0.05 and **P < 0.01). Chad Paul Grabner, and Tobias Moser PNAS doi:10.1073/pnas.1811814115 ©2018 by National Academy of Sciences