Halothane potentiates the effect of methamphetamine and nomifensine on extracellular dopamine levels in rat striatum: a microdialysis study Y.U. Adachi,

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Halothane potentiates the effect of methamphetamine and nomifensine on extracellular dopamine levels in rat striatum: a microdialysis study Y.U. Adachi, K. Watanabe, T. Satoh, E.S. Vizi British Journal of Anaesthesia Volume 86, Issue 6, Pages 837-845 (June 2001) DOI: 10.1093/bja/86.6.837 Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 1 Effect of halothane anaesthesia on concentrations of extracellular dopamine and its metabolites (3-MT, DOPAC and HVA). In this and following figures, the ordinate of each graph shows the level of dopamine or its metabolites expressed as the percentage of the baseline concentration, which is the mean of three consecutive values immediately before the start of halothane anaesthesia; each point is the mean (sem) (n=6); dialysate fractions were obtained every 20 min. Asterisks indicate significant changes (P<0.05; Newman–Keuls post hoc comparison) compared with the control value at the corresponding time point. British Journal of Anaesthesia 2001 86, 837-845DOI: (10.1093/bja/86.6.837) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 2 Effects of systemically administered methamphetamine 2 mg kg–1 on the concentrations of extracellular dopamine and its metabolites with or without halothane anaesthesia. Asterisks indicate significant changes (P<0.05; Newman–Keuls post hoc comparison) compared with the control value (without anaesthesia) at the corresponding time point. British Journal of Anaesthesia 2001 86, 837-845DOI: (10.1093/bja/86.6.837) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 3 Effects of locally administered methamphetamine (2 mg kg–1) on the concentrations of extracellular dopamine and its metabolites with and without halothane anaesthesia. Asterisks indicate significant changes (P<0.05; Newman–Keuls post hoc comparison) compared with the control value (without anaesthesia) at the corresponding time point. British Journal of Anaesthesia 2001 86, 837-845DOI: (10.1093/bja/86.6.837) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 4 Effects of systemically administered nomifensine (10 mg kg–1) on the concentrations of extracellular dopamine and its metabolites with and without halothane anaesthesia. Asterisks indicate significant changes (P<0.05; Newman–Keuls post hoc comparison) compared with the control value (without anaesthesia) at the corresponding time point. British Journal of Anaesthesia 2001 86, 837-845DOI: (10.1093/bja/86.6.837) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions

Fig 5 Effects of locally administered nomifensine (10 mg kg–1) on the levels of extracellular dopamine and its metabolites with and without halothane anaesthesia. Asterisks indicate significant changes (P<0.05; Newman–Keuls post hoc comparison) compared with the control value (without anaesthesia) at the corresponding time point. British Journal of Anaesthesia 2001 86, 837-845DOI: (10.1093/bja/86.6.837) Copyright © 2001 British Journal of Anaesthesia Terms and Conditions