T1ρ and T2 relaxation times predict progression of knee osteoarthritis

Slides:

Advertisements

Similar presentations

Changes in patellofemoral and tibiofemoral joint cartilage damage and bone marrow lesions over 7 years: the Multicenter Osteoarthritis Study J.J. Stefanik,

Advertisements

Whole joint MRI assessment of surgical cartilage repair of the knee: Cartilage Repair OsteoArthritis Knee Score (CROAKS) F.W. Roemer, A. Guermazi, S.

Subregional laminar cartilage MR spin–spin relaxation times (T2) in osteoarthritic knees with and without medial femorotibial cartilage loss – data from.

Validity and responsiveness of a new measure of knee osteophytes for osteoarthritis studies: data from the osteoarthritis initiative M. Hakky, M. Jarraya,

T1ρ relaxation time of the meniscus and its relationship with T1ρ of adjacent cartilage in knees with acute ACL injuries at 3T R.I. Bolbos, Ph.D., T.M.

Functional cartilage MRI T2 mapping: evaluating the effect of age and training on knee cartilage response to running T.J. Mosher, Y. Liu, C.M. Torok

Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST study F.W. Roemer, T. Neogi,

Changes in patellofemoral and tibiofemoral joint cartilage damage and bone marrow lesions over 7 years: the Multicenter Osteoarthritis Study J.J. Stefanik,

Imaging following acute knee trauma

Predictive validity of within-grade scoring of longitudinal changes of MRI-based cartilage morphology and bone marrow lesion assessment in the tibio-femoral.

Trabecular bone structure and spatial differences in articular cartilage MR relaxation times in individuals with posterior horn medial meniscal tears

MRI of articular cartilage in OA: novel pulse sequences and compositional/functional markers Garry E. Gold, Deborah Burstein, Bernard Dardzinski, Phillip.

Imaging of non-osteochondral tissues in osteoarthritis

Osteoarthritis and Cartilage

7th International Workshop on Osteoarthritis Imaging report: “imaging in OA – now is the time to move ahead” A. Guermazi, F. Eckstein, D. Hunter, F.

Intraoperative validation of quantitative T2 mapping in patients with articular cartilage lesions of the knee S.T. Soellner, A. Goldmann, D. Muelheims,

Cartilage MRI T2∗ relaxation time and perfusion changes of the knee in a 5/6 nephrectomy rat model of chronic kidney disease C.-Y. Wang, Y.-J. Peng,

A novel fast knee cartilage segmentation technique for T2 measurements at MR imaging – data from the Osteoarthritis Initiative C. Stehling, T. Baum,

Altered regional loading patterns on articular cartilage following meniscectomy are not fully restored by autograft meniscal transplantation H. Wang,

The effect of anterior cruciate ligament injury on bone curvature: exploratory analysis in the KANON trial D.J. Hunter, L.S. Lohmander, J. Makovey, J.

Women have thinner cartilage and smaller joint surfaces than men after adjustment for body height and weight I.G. Otterness, Ph.D., F. Eckstein, M.D.

M. C. Gallo, C. Wyatt, V. Pedoia, D. Kumar, S. Lee, L. Nardo, T. M

Quantitatively-measured bone marrow lesions in the patellofemoral joint: distribution and association with pain C. Ratzlaff, R. Russell, J. Duryea Osteoarthritis.

Differences between X-ray and MRI-determined knee cartilage thickness in weight- bearing and non-weight-bearing conditions M. Marsh, R.B. Souza, B.T.

Structural correlates of pain in joints with osteoarthritis

Bone and cartilage demonstrate changes localized to bone marrow edema-like lesions within osteoarthritic knees G.J. Kazakia, D. Kuo, J. Schooler, S.

Demographic and biomechanical factors related to structural progression of hip osteoarthritis over 18 months D. Kumar, C. Wyatt, N. Okazaki, K. Chiba,

Magnetic resonance imaging lesions are more severe and cartilage T2 relaxation time measurements are higher in isolated lateral compartment radiographic.

Volumetric and semiquantitative assessment of MRI-detected subchondral bone marrow lesions in knee osteoarthritis: a comparison of contrast-enhanced and.

Spontaneous osteoarthritis in Str/ort mice is unlikely due to greater vulnerability to mechanical trauma B. Poulet, T.A.T. Westerhof, R.W. Hamilton,

Whole joint MRI assessment of surgical cartilage repair of the knee: Cartilage Repair OsteoArthritis Knee Score (CROAKS) F.W. Roemer, A. Guermazi, S.

Comparison between semiquantitative and quantitative methods for the assessment of knee synovitis in osteoarthritis using non-enhanced and gadolinium-enhanced.

Vastus lateralis/vastus medialis cross-sectional area ratio impacts presence and degree of knee joint abnormalities and cartilage T2 determined with 3T.

M. A. McNulty, R. F. Loeser, C. Davey, M. F. Callahan, C. M

Preclinical investigation of the development of osteoarthritis-like degeneration in a rat trauma model using micro-computed tomography T.H. Steiner,

J. Ranstam Osteoarthritis and Cartilage

Is increased joint loading detrimental to obese patients with knee osteoarthritis? A secondary data analysis from a randomized trial M. Henriksen, D.J.

Osteoarthritis may not be a one-way-road of cartilage loss – comparison of spatial patterns of cartilage change between osteoarthritic and healthy knees

D. Hayashi, F.W. Roemer, A. Guermazi Osteoarthritis and Cartilage

Baseline mean and heterogeneity of MR cartilage T2 are associated with morphologic degeneration of cartilage, meniscus, and bone marrow over 3years –

Pre-radiographic osteoarthritic changes are highly prevalent in the medial patella and medial posterior femur in older persons: Framingham OA study D.

Bone marrow lesions and joint effusion are strongly and independently associated with weight-bearing pain in knee osteoarthritis: data from the osteoarthritis.

Rates and sensitivity of knee cartilage thickness loss in specific central reading radiographic strata from the osteoarthritis initiative S. Maschek,

Degeneration of patellar cartilage in patients with recurrent patellar dislocation following conservative treatment: evaluation with delayed gadolinium-enhanced.

Structural changes in the knee during weight loss maintenance after a significant weight loss in obese patients with osteoarthritis: a report of secondary.

Comments on Beattie et al

Magnetic resonance imaging (MRI)-defined cartilage degeneration and joint pain are associated with poor physical function in knee osteoarthritis – the.

Classification of graft hypertrophy after autologous chondrocyte implantation of full- thickness chondral defects in the knee P.C. Kreuz, M.D., M. Steinwachs,

Volumetric bone mineral density of the tibia is not increased in subjects with radiographic knee osteoarthritis M. Abdin-Mohamed, M.B.B.S., M.R.C.P.,

A reference database of cartilage 3 T MRI T2 values in knees without diagnostic evidence of cartilage degeneration: data from the osteoarthritis initiative

Comparison of BLOKS and WORMS scoring systems part I

Racial differences in biochemical knee cartilage composition between African-American and Caucasian-American women with 3 T MR-based T2 relaxation time.

MRI-derived T2 relaxation times and cartilage morphometry of the tibio-femoral joint in subjects with and without osteoarthritis during a 1-year follow-up

X. Li, Ph. D. , C. Benjamin Ma, M. D. , T. M. Link, M. D. , D. -D

Association of cartilage defects, and other MRI findings with pain and function in individuals with mild–moderate radiographic hip osteoarthritis and.

Elevated cartilage T2 and increased severity of cartilage defects at baseline are associated with the development of knee pain over 7 years G.B. Joseph,

D.J. Hunter Osteoarthritis and Cartilage

The association between hip bone marrow lesions and bone mineral density: a cross- sectional and longitudinal population-based study H. Ahedi, D. Aitken,

Degenerative knee joint disease in mice lacking 3′-phosphoadenosine 5′-phosphosulfate synthetase 2 (Papss2) activity: a putative model of human PAPSS2.

Altered gait mechanics and elevated serum pro-inflammatory cytokines in asymptomatic patients with MRI evidence of knee cartilage loss S.N. Edd, J. Favre,

Longitudinal evaluation of T1ρ and T2 spatial distribution in osteoarthritic and healthy medial knee cartilage J. Schooler, D. Kumar, L. Nardo, C. McCulloch,

Knee cartilage defects in a sample of older adults: natural history, clinical significance and factors influencing change over 2.9 years J. Carnes, O.

Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen.

G. Blumenkrantz, B. S. , R. Stahl, M. D. , J. Carballido-Gamio, Ph. D

Osteoarthritis and Cartilage

Preliminary study on diffraction enhanced radiographic imaging for a canine model of cartilage damage C. Muehleman, Ph.D., J. Li, M.D., Z. Zhong, Ph.D.

Baseline magnetic resonance imaging cartilage T2 relaxation time measurements as predictors of total knee arthroplasty in African-Americans – Data from.

Osteoarthritis year 2012 in review: imaging

Longitudinal analysis of cartilage T2 relaxation times and joint degeneration in African American and Caucasian American women over an observation period.

Quantifying biochemical changes in the cartilage matrix in osteoarthritic knee after hyaluronic acid injection using quantitative MR techniques A.R.

Presentation transcript:

T1ρ and T2 relaxation times predict progression of knee osteoarthritis A.P. Prasad, L. Nardo, J. Schooler, G.B. Joseph, T.M. Link Osteoarthritis and Cartilage Volume 21, Issue 1, Pages 69-76 (January 2013) DOI: 10.1016/j.joca.2012.09.011 Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Sagittal, intermediate-weighted MR images demonstrate progression of a cartilage lesion at the PAT: at baseline (a) a small amount of partial-thickness cartilage loss at the inferior pole of the patella (short arrow) associated with bone marrow edema is seen and at the 12 month-follow-up (b) extensive full-thickness cartilage loss is shown at the same site (long arrow). Osteoarthritis and Cartilage 2013 21, 69-76DOI: (10.1016/j.joca.2012.09.011) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Dot plot showing T2 relaxation time values, stratified by progression vs non-progression. SDs are also depicted, asterisks (*) indicate statistical significance between the two groups (P < 0.05). Osteoarthritis and Cartilage 2013 21, 69-76DOI: (10.1016/j.joca.2012.09.011) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Sagittal T2 color maps (a, d) with baseline (b, e) and follow-up (c, f) sagittal intermediate-weighted MR images. Low T2 values (a) are associated with intact patella cartilage both at the baseline (b) and at the follow-up (c) (non-progressor). High T2 values (d) are associated with extensive progression of femoral and tibial cartilage degeneration: (e) partial femoral and tibial cartilage defects at baseline (arrow) progress in the follow-up (f) with full-thickness loss and partial-thickness cartilage loss at the tibia (long arrow). In addition new bone marrow edema pattern is shown at the femur and tibia (short arrow). Osteoarthritis and Cartilage 2013 21, 69-76DOI: (10.1016/j.joca.2012.09.011) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Dot plot showing T1ρ relaxation time values, stratified by progression vs non-progression. SDs are also depicted, asterisks (*) indicate statistical significance between the two groups (P < 0.05). Osteoarthritis and Cartilage 2013 21, 69-76DOI: (10.1016/j.joca.2012.09.011) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions

Fig. 5 Sagittal T1ρ color maps (a,d) with baseline (b,e) and follow-up (c,f) sagittal morphological MR images. In (a) the T1ρ color map demonstrates low patellar T1ρ values at baseline (average value 30). Baseline (b) and follow-up (c) depict intact patellar cartilage with no degeneration (c). In (d) the T1ρ color map shows high patellar values at baseline (average value about 40). Baseline (e) and follow-up (f) demonstrate progression of a cartilage lesion at the patella: at baseline mild fissuring of the cartilage at the patella is shown (short arrow) associated with bone marrow edema pattern (long arrow) and at the follow-up (f) progression to extensive full-thickness cartilage loss is noted at this site (arrow). Osteoarthritis and Cartilage 2013 21, 69-76DOI: (10.1016/j.joca.2012.09.011) Copyright © 2012 Osteoarthritis Research Society International Terms and Conditions