The Y-Family of DNA Polymerases

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The Y-Family of DNA Polymerases Haruo Ohmori, Errol C. Friedberg, Robert P.P. Fuchs, Myron F. Goodman, Fumio Hanaoka, David Hinkle, Thomas A. Kunkel, Christopher W. Lawrence, Zvi Livneh, Takehiko Nohmi, Louise Prakash, Satya Prakash, Takeshi Todo, Graham C. Walker, Zhigang Wang, Roger Woodgate Molecular Cell Volume 8, Issue 1, Pages 7-8 (July 2001) DOI: 10.1016/S1097-2765(01)00278-7

Figure 1 Unrooted Phyogenetic Tree of the Y-Family of Polymerases Members of the family were identified by a BlastP search of the nonredundant protein database using the IMS (ImpB/MucB/SamB) consensus as the query. Nearly 100 hits were obtained, and the results were filtered by the removal of fragments or sequences with over 97% identity. Proteins were aligned using the ClustalX program and modified manually to ensure the correct alignment of conserved motifs. The tree can be broadly divided into several branches that include UmuC-Gram negative (shaded in yellow), UmuC-Gram positive (shaded in orange), DinB (shaded in red), Rev1 (shaded in indigo), Rad30B (shaded in blue), and Rad30A (shaded in green). The abbreviations used in the figure are as follows: Bacteria: Ban, Bacillus anthracis; Bha, Bacillus halodurans; Bsu, Bacillus subtilis; Cfr, Citrobacter freundii; Eco, Escherichia coli; Efa, Enterococcus faecalis; Lla, Lactococcus lactis; Mge, Mycoplasma genitalium; Mmo, Morganella morganii; Mpn, Mycoplasma pneumoniae; Mtu, Mycobacterium tuberculosis; Nme, Neisseria meningitides; Pae, Pseudomonas aeruginosa; Pmu, Pasteurella multocida; Psy, Pseudomonas syringae; Sco, Streptomyces coelicolor; Sen, Salmonella enterica; Sfl, Shigella flexneri; Sma, Serratia marcescens; Spn, Streptococcus pneumoniae; Sth, Salmonella typhi; Sty, Salmonella typhimurium; Uur, Ureaplasma urealyticum; Vco, Vibrio cholerae. Archaea: Hal, Halobacterium sp. NRC-11; Sso, Sulfolobus solfataricus. Eukaryotes: At, Arabidopsis thaliana; Ce, Caenorhabditis elegans; Dm, Drosophila melanogoster; Hs, Homo sapiens; Lm, Leishmania major; Mm, Mus musculus; Sc, Saccharomyces cerevisiae; Sp, Schizosaccharomyces pombe. Molecular Cell 2001 8, 7-8DOI: (10.1016/S1097-2765(01)00278-7)