Young H. Lim, Jonathan M. Fisher, Marcus W. Bosenberg, Keith A

Slides:



Advertisements
Similar presentations
Topically applied ascorbic acid solution for the treatment of basal cell carcinoma (BCC)  Péter Holló, MD, PhD, Hajnalka Jókai, MD, PhD, Judit Hársing,
Advertisements

Triple-Negative Breast Cancer
CD47 expression for in situ and invasive cutaneous epithelial lesions
Young H. Lim, Stephanie R. Douglas, Christine J. Ko, Richard J
Ex vivo fluorescence confocal microscopy in conjunction with Mohs micrographic surgery for cutaneous squamous cell carcinoma  Caterina Longo, MD, PhD,
MAGEA3 Expression in Cutaneous Squamous Cell Carcinoma Is Associated with Advanced Tumor Stage and Poor Prognosis  Melody Abikhair, Nazanin Roudiani,
Sarah A. Best, Amy N. Nwaobasi, Chrysalyne D. Schmults, Matthew R
Genetic Reversion via Mitotic Recombination in Ichthyosis with Confetti due to a KRT10 Polyalanine Frameshift Mutation  Young H. Lim, Jingyao Qiu, Corey.
Keratoacanthomas associated with sorafenib therapy
Genetic Profiling of BRAF Inhibitor–Induced Keratoacanthomas Reveals No Induction of MAP Kinase Pathway Expression  Rajan P. Kulkarni, Seema Plaisier,
Jonathan L. Levinsohn, Li C. Tian, Lynn M. Boyden, Jennifer M
Exploring the relationship between natural killer cells and cutaneous squamous cell carcinoma development  Muneeb Ilyas, BSc, Collin M. Costello, BS,
Jack L. Arbiser, Michael Y. Bonner 
Sarah A. Best, Amy N. Nwaobasi, Chrysalyne D. Schmults, Matthew R
Topical ROR Inverse Agonists Suppress Inflammation in Mouse Models of Atopic Dermatitis and Acute Irritant Dermatitis  Jun Dai, Min-Kyung Choo, Jin Mo.
Spindle-Cell Variants of Primary Cutaneous Follicle Center B-Cell Lymphomas Are Germinal Center B-Cell Lymphomas by Gene Expression Profiling Using a.
JAK1/2 Inhibitor Ruxolitinib Controls a Case of Chilblain Lupus Erythematosus  Joerg Wenzel, Nadine van Holt, Judith Maier, Maria Vonnahme, Thomas Bieber,
Skin-Derived Vitamin D3 Protects against Basal Cell Carcinoma
Jason E. Hawkes, Johann E. Gudjonsson, Nicole L. Ward 
Survival of Patients with Cutaneous Squamous Cell Carcinoma: Results of a Prospective Cohort Study  Thomas K. Eigentler, Ulrike Leiter, Hans-Martin Häfner,
William E. Lowry, Aimee Flores, Andrew C. White 
Holly Anderton, James A. Rickard, George A
Aspirin and Nonsteroidal Anti-Inflammatory Drugs Can Prevent Cutaneous Squamous Cell Carcinoma: a Systematic Review and Meta-Analysis  Chiho Muranushi,
Michael L. Frisoli, John E. Harris 
Inflammatory Linear Verrucous Epidermal Nevus with a Postzygotic GJA1 Mutation Is a Mosaic Erythrokeratodermia Variabilis et Progressiva  Noriko Umegaki-Arao,
Amel A. Albibas, Matthew J. J. Rose-Zerilli, Chester Lai, Reuben J
Clinical Snippets Journal of Investigative Dermatology
Epidermal Desmoglein 1 Expression Is Reduced in Kidney Transplant Recipients Compared with Immunocompetent Patients  Jodi L. Johnson, Paul Hoover, Borko.
Jean Claude Dusingize, Catherine M. Olsen, Nirmala P
Enhanced Cutaneous Inflammatory Reactions to Aspergillus fumigatus in a Murine Model of Chronic Granulomatous Disease  Jeffrey E. Petersen  Journal of.
Antonio Julià  Journal of Investigative Dermatology 
Kavitha K. Reddy  Journal of Investigative Dermatology 
Molecular Profiling of Immune Activation Associated with Regression of Melanoma Metastases Induced by Diphencyprone  Nicholas Gulati, Sandra Garcet, Judilyn.
Mutational Analysis of BRAF Inhibitor–Associated Squamoproliferative Lesions  Britt Clynick, Tania Tabone, Kathryn Fuller, Wendy Erber, Katie Meehan, Michael.
Plasmacytoid dendritic cell involvement in the host response against keratoacanthoma  Ossama Abbas, MD, Lama Hussein, MD, Mazen Kurban, MD, Abdul-Ghani.
Joanne E. Sordillo, Peter Kraft, Ann Chen Wu, Maryam M. Asgari 
NRAS, NRAS, Which Mutation Is Fairest of Them All?
Volume 2, Issue 3, Pages (May 2016)
The BRAF Inhibitor Vemurafenib Enhances UV-Induced Skin Carcinogenesis in Beta HPV38 E6 and E7 Transgenic Mice  Daniele Viarisio, Karin Müller-Decker,
Clinical Snippets Journal of Investigative Dermatology
Research Techniques Made Simple: Cost-Effectiveness Analysis
Novel Mutations Involving NF-κB and B-Cell Signaling Pathways in Primary Cutaneous Large B-Cell Lymphoma, Leg-Type and Comparison with Sézary Syndrome 
Symptomatic Improvement in Human Papillomavirus-Induced Epithelial Neoplasia by Specific Targeting of the CXCR4 Chemokine Receptor  Floriane Meuris, Françoise.
IL-27 Suppresses Antimicrobial Activity in Human Leprosy
Volume 4, Issue 7, Pages (August 2018)
Geraldine O’Sullivan Coyne, Therese S. Woodring, Chyi-Chia R
Tamar Nijsten  Journal of Investigative Dermatology 
Zika Virus Infection RIG-ged by Keratinocytes and Fibroblasts
Mary Eid, Jannett Nguyen, Isaac Brownell 
Yuko Oda, Lizhi Hu, Vadim Bul, Hashem Elalieh, Janardan K
More Than Many: How to Manage the Most Frequent Cancer?
J. Claire Hoving, Natalie E. Nieuwenhuizen, Georgia Schäfer, Arieh A
Nrf2 Promotes Keratinocyte Proliferation in Psoriasis through Up-Regulation of Keratin 6, Keratin 16, and Keratin 17  Luting Yang, Xueli Fan, Tingting.
Maryam M. Asgari, Wei Wang, Nilah M
Cancer Stem Cells in Squamous Cell Carcinoma
Somatic Mutations of Fas (Apo-1/CD95) Gene in Cutaneous Squamous Cell Carcinoma Arising from a Burn Scar  Sug Hyung Lee, Min Sun Shin, Hong Sug Kim, Won.
Clinical Snippets Journal of Investigative Dermatology
Sigrun A.J. Schmidt, Serigne Lo, Loes M. Hollestein 
Research Techniques Made Simple: Itch Measurement in Clinical Trials
Journal of Investigative Dermatology
Society for Investigative Dermatology 2010 Meeting Minutes
Journal of Investigative Dermatology
Staphylococcus epidermidis Sets Things Right Again
Erratum Journal of Investigative Dermatology
Journal of Investigative Dermatology
Jonathan L. Levinsohn, Jeffrey L. Sugarman, Kaya Bilguvar, Jennifer M
Decrease of Skin Infiltrating and Circulating CCR10+ T Cells Coincides with Clinical Improvement after Topical Tacrolimus in Omenn Syndrome  Claudia M.
Journal of Investigative Dermatology
Journal of Investigative Dermatology
Topically applied ascorbic acid solution for the treatment of basal cell carcinoma (BCC)  Péter Holló, MD, PhD, Hajnalka Jókai, MD, PhD, Judit Hársing,
Presentation transcript:

Keratoacanthoma Shares Driver Mutations with Cutaneous Squamous Cell Carcinoma  Young H. Lim, Jonathan M. Fisher, Marcus W. Bosenberg, Keith A. Choate, Christine J. Ko  Journal of Investigative Dermatology  Volume 136, Issue 8, Pages 1737-1741 (August 2016) DOI: 10.1016/j.jid.2016.04.002 Copyright © 2016 The Authors Terms and Conditions

Figure 1 Clinical and histologic features of KA and driver mutation profiles. Clinical presentation and histopathology (original magnification ×4) of (a, b) KA100, (c, d) KA101, (e, f) KA102, (g, h) KA103, (i, j) KA104, and (k, l) KA105. All lesions are crateriform with a pink, stretched border and central keratin. The partial biopsy samples show epithelium of varying thickness and atypia bordering central keratin. The greatest atypia is present in KA104 (j). (m) Mutations in known driver genes of cutaneous squamous cell carcinoma were found in all growing KAs (samples in red) and 50% of vemurafenib-induced squamous lesions but were absent in regressing lesions (samples in green). Paired lesions at different stages of KA (asterisks) showed loss of driver mutation during regression. Keratinocytic regions were targeted for sampling tissue for DNA to avoid significant admixture with inflammatory infiltrates (plus signs). Scale bars = 50 μm. KA, keratoacanthoma; VSL, vemurafenib-induced squamoproliferative lesion. Journal of Investigative Dermatology 2016 136, 1737-1741DOI: (10.1016/j.jid.2016.04.002) Copyright © 2016 The Authors Terms and Conditions