Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug- induced cutaneous eruptions Nikhil Yawalkar, MD, Maithili Shrikhande,

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Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug- induced cutaneous eruptions Nikhil Yawalkar, MD, Maithili Shrikhande, MD, Yvonne Hari, MD, Helga Nievergelt, MD, Lasse R. Braathen, MD, Werner J. Pichler, MD Journal of Allergy and Clinical Immunology Volume 106, Issue 6, Pages 1171-1176 (December 2000) DOI: 10.1067/mai.2000.110922 Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 1 Representative histology of a drug-induced maculopapular exanthem showing a superficial mixed inflammatory cell infiltration with eosinophils (arrows; original magnification 250×). Journal of Allergy and Clinical Immunology 2000 106, 1171-1176DOI: (10.1067/mai.2000.110922) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 2 Numbers of eosinophils in skin and blood from normal control subjects (n = 9), patients with a drug-induced maculopapular exanthem (n = 9), and patients with psoriasis (n = 8). Journal of Allergy and Clinical Immunology 2000 106, 1171-1176DOI: (10.1067/mai.2000.110922) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 3 Localization of IL-5, eotaxin, RANTES, MCP-3, and IL-8 immunoreactivity. Representative examples from skin sections from normal skin (a-e) , one patient with a drug-induced maculopapular exanthem (f-j) , and from skin of a patient with psoriasis (k-o) are shown. Arrows indicate positively stained cells (original magnification 250×). Journal of Allergy and Clinical Immunology 2000 106, 1171-1176DOI: (10.1067/mai.2000.110922) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 4 Quantification of IL-5–, eotaxin-, RANTES-, MCP-3–, and IL-8–positive cells in normal control subjects (n = 9), patients with a drug-induced maculopapular exanthem (n = 9), and patients with psoriasis (n = 8). Mean values ± SEM are shown, and statistical analysis is indicated. Journal of Allergy and Clinical Immunology 2000 106, 1171-1176DOI: (10.1067/mai.2000.110922) Copyright © 2000 Mosby, Inc. Terms and Conditions

Fig. 5 IL-5 is highly expressed in T lymphocytes in drug-induced maculopapular exanthem. Consecutive skin sections stained with anti-IL-5 (a) and anti-CD3 (b) are shown. Journal of Allergy and Clinical Immunology 2000 106, 1171-1176DOI: (10.1067/mai.2000.110922) Copyright © 2000 Mosby, Inc. Terms and Conditions