Impact of a hospital-wide multifaceted programme for reducing carbapenem-resistant Enterobacteriaceae infections in a large teaching hospital in northern.

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Impact of a hospital-wide multifaceted programme for reducing carbapenem-resistant Enterobacteriaceae infections in a large teaching hospital in northern Italy P. Viale, F. Tumietto, M. Giannella, M. Bartoletti, S. Tedeschi, S. Ambretti, F. Cristini, C. Gibertoni, S. Venturi, M. Cavalli, A. De Palma, M.C. Puggioli, D. Mosci, E. Callea, R. Masina, M.L. Moro, R.E. Lewis Clinical Microbiology and Infection Volume 21, Issue 3, Pages 242-247 (March 2015) DOI: 10.1016/j.cmi.2014.10.020 Copyright © 2014 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Pre-intervention and post-intervention trends in the monthly incidence of carbapenem-resistant Enterobacteriaceae (CRE) bloodstream infection (BSI). A significant decline in the monthly incidence rate ratio (IRR) of CRE BSI during the 30-month post-intervention period was found by Poisson regression. Clinical Microbiology and Infection 2015 21, 242-247DOI: (10.1016/j.cmi.2014.10.020) Copyright © 2014 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 Trends in the number of rectal swabs performed per month (solid line, left y-axis) and the percentage of cultures positive for carbapenem-resistant Enterobacteriaceae (CRE) (dotted line, right y-axis). The solid line superimposed on the percenaget rate of positive CRE swabs (dotted line) indicates the significant decline in the trend of the incidence rate ratio (IRR) by Poisson regression. Clinical Microbiology and Infection 2015 21, 242-247DOI: (10.1016/j.cmi.2014.10.020) Copyright © 2014 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 3 Relationship between average institutional compliance rates for rectal screening (bars, right y-axis) and monthly incidence of CRE-positive rectal swabs (solid line, left y-axis) and bloodstream infection (dotted line, left-axis). Clinical Microbiology and Infection 2015 21, 242-247DOI: (10.1016/j.cmi.2014.10.020) Copyright © 2014 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions