Breaking Down Neighbors to Fuel Tumorigenesis

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Breaking Down Neighbors to Fuel Tumorigenesis John Vaughen, Tatsushi Igaki Developmental Cell Volume 40, Issue 3, Pages 219-220 (February 2017) DOI: 10.1016/j.devcel.2017.01.011 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Tumors Trigger Non-autonomous Autophagy Both Locally and Systemically (A) Drosophila larvae harboring RasV12, scrib−/− tumors (green) in eye-antennal discs (EAD) undergo systemic autophagy. Tumors can metastasize from brain lobes (BL) and/or EAD into ventral nerve cord (VNC). (B) Local non-autonomous autophagy (NAA) fuels RasV12, scrib−/− growth and metastasis. JNK, Yki, and autocrine JAK-STAT signaling activated by Upd/IL-6 trigger NAA. NAA may contribute to tumor growth by providing nutrients to tumors, including through the amino acid transporter Slimfast. Developmental Cell 2017 40, 219-220DOI: (10.1016/j.devcel.2017.01.011) Copyright © 2017 Elsevier Inc. Terms and Conditions