Selective Priming of Syntactic Processing by Event-Related Transcranial Magnetic Stimulation of Broca's Area  Kuniyoshi L Sakai, Yasuki Noguchi, Tatsuya.

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Selective Priming of Syntactic Processing by Event-Related Transcranial Magnetic Stimulation of Broca's Area  Kuniyoshi L Sakai, Yasuki Noguchi, Tatsuya Takeuchi, Eiju Watanabe  Neuron  Volume 35, Issue 6, Pages 1177-1182 (September 2002) DOI: 10.1016/S0896-6273(02)00873-5

Figure 1 The Targeted Regions in the Left Prefrontal Cortex Horizontal (A) and coronal (B) MR images indicating the position of the TMS coil for a representative subject. In each panel, the nearest MR marker to the center of the coil, which locates over the center of the left F3op/F3t, is shown (arrow for the stimulated site). The stimulation sites in the left F3op/F3t and in the left F2 are labeled as sites I and II, respectively, on the lateral surface image of the MNI standard brain (C). a, the precentral sulcus; b, the inferior frontal sulcus; c, the superior frontal sulcus. Neuron 2002 35, 1177-1182DOI: (10.1016/S0896-6273(02)00873-5)

Figure 2 Language Tasks with a Minimal Pair Paradigm Normal (N) sentences used in the two tasks were physically identical. In a syntactic decision (Syn) task, syntactically anomalous (Syn A) sentences were intermixed with normal sentences. In a semantic decision (Sem) task, semantically anomalous (Sem A) sentences were intermixed with normal sentences. Arrows on the time scale indicate three time points of TMS: T = 0, 150, and 350 ms from the presentation of a verb. Acc, accusative case particle; vt, transitive verb; vi, intransitive verb. Neuron 2002 35, 1177-1182DOI: (10.1016/S0896-6273(02)00873-5)

Figure 3 Selective Priming Effects of TMS on Syntactic Processing at the Left F3op/F3t ΔRT (mean and standard error across subjects) indicates the change of RTs (Real − Sham) elicited by the TMS. Each bar denotes ΔRT for either normal (N) or anomalous (A) sentences. TMS was delivered at one of three time points: 0 ms (A), 150 ms (B), and 350 ms (C) from the presentation of a verb. *p < 0.05, **p < 0.01 (t test, n = 6). Neuron 2002 35, 1177-1182DOI: (10.1016/S0896-6273(02)00873-5)

Figure 4 The Absence of TMS Effects on the Language Tasks at the Left F2 Each bar denotes ΔRT for either N or A sentences. TMS was delivered at 150 ms from the presentation of a verb. Neuron 2002 35, 1177-1182DOI: (10.1016/S0896-6273(02)00873-5)