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Change in fluorescence / min pH-GluR2L T912A pH-GluR2L T912D pH-GluR2Lwt Change in fluorescence / min Supplementary Figure 11: Status of the novel T912 site does not affect initial rates of pHGluR2L internalization induced by NMDA treatment of cultured neurons. The indicated constructs were expressed in primary hippocampal neurons as in Fig 6 and treated with NMDA. The initial rate of internalization (which is approximately linear, see Fig 6c-f) for each construct.was plotted as mean + S.E.M. pHGluR2Lwt, N=8; pHGluR2L T912A, N=5; pHGluR2L T912D, N=4.