Figure 1 The sensory and secretory function of the L cell

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Figure 1 The sensory and secretory function of the L cell Figure 1 | The sensory and secretory function of the L cell. Release of glucagon-like peptide 1 (GLP-1) from L cells is regulated by nutritional, hormonal and neural signals. Food components and metabolites at the luminal side of the L cell are directly sensed by various G protein-coupled receptors that function as chemosensors and trigger exocytosis of GLP-1-containing granules at the basolateral side of the cell. GLP-1 can act through endocrine, paracrine and neuronal pathways to regulate physiological responses in local and/or remote tissues and cell types. These effects are consistent with the widespread and abundant expression of the GLP-1 receptor. LCFA, long-chain fatty acid; SCFA, short-chain fatty acid. Muskiet, M. H. A. et al. (2017) GLP-1 and the kidney: from physiology to pharmacology and outcomes in diabetes Nat. Rev. Nephrol. doi:10.1038/nrneph.2017.123