Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis Motohiro Kurosawa, MD,

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Presentation transcript:

Heterogeneity of mast cells in mastocytosis and inhibitory effect of ketotifen and ranitidine on indolent systemic mastocytosis Motohiro Kurosawa, MD, PhD, PharmDa, Hiroo Amano, MDa, Naotomo Kanbe, MDa, Sachiko Akimoto, MD, PhDa, Yuko Takeuchia, Tetsuji Yamashita, BSb, Tsutomu Hashimoto, BSb, Fumihiko Kurimoto, BSb, Yoshiki Miyachi, MD, PhDa Journal of Allergy and Clinical Immunology Volume 100, Issue 6, Pages S25-S32 (December 1997) DOI: 10.1016/S0091-6749(97)70001-0 Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 1 Staining patterns of lesional skin (×160 magnification) from an 11-month-old boy with urticaria pigmentosa. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology 1997 100, S25-S32DOI: (10.1016/S0091-6749(97)70001-0) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 1 Staining patterns of lesional skin (×160 magnification) from an 11-month-old boy with urticaria pigmentosa. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology 1997 100, S25-S32DOI: (10.1016/S0091-6749(97)70001-0) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 1 Staining patterns of lesional skin (×160 magnification) from an 11-month-old boy with urticaria pigmentosa. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology 1997 100, S25-S32DOI: (10.1016/S0091-6749(97)70001-0) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 1 Staining patterns of lesional skin (×160 magnification) from an 11-month-old boy with urticaria pigmentosa. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology 1997 100, S25-S32DOI: (10.1016/S0091-6749(97)70001-0) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 2 Staining patterns of gastric mucosa (×160 magnification) from a 41-year-old man with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology 1997 100, S25-S32DOI: (10.1016/S0091-6749(97)70001-0) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 2 Staining patterns of gastric mucosa (×160 magnification) from a 41-year-old man with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology 1997 100, S25-S32DOI: (10.1016/S0091-6749(97)70001-0) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 2 Staining patterns of gastric mucosa (×160 magnification) from a 41-year-old man with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology 1997 100, S25-S32DOI: (10.1016/S0091-6749(97)70001-0) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 2 Staining patterns of gastric mucosa (×160 magnification) from a 41-year-old man with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology 1997 100, S25-S32DOI: (10.1016/S0091-6749(97)70001-0) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 3 Staining patterns of nonlesional skin (×160 magnification) from the patient with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology 1997 100, S25-S32DOI: (10.1016/S0091-6749(97)70001-0) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 3 Staining patterns of nonlesional skin (×160 magnification) from the patient with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology 1997 100, S25-S32DOI: (10.1016/S0091-6749(97)70001-0) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 3 Staining patterns of nonlesional skin (×160 magnification) from the patient with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology 1997 100, S25-S32DOI: (10.1016/S0091-6749(97)70001-0) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 3 Staining patterns of nonlesional skin (×160 magnification) from the patient with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology 1997 100, S25-S32DOI: (10.1016/S0091-6749(97)70001-0) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 4 Staining patterns of lesional skin (×160 magnification) from the patient with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology 1997 100, S25-S32DOI: (10.1016/S0091-6749(97)70001-0) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 4 Staining patterns of lesional skin (×160 magnification) from the patient with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology 1997 100, S25-S32DOI: (10.1016/S0091-6749(97)70001-0) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 4 Staining patterns of lesional skin (×160 magnification) from the patient with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology 1997 100, S25-S32DOI: (10.1016/S0091-6749(97)70001-0) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 4 Staining patterns of lesional skin (×160 magnification) from the patient with indolent systemic mastocytosis. A, Hematoxylin and eosin stain. B, Toluidine blue stain. C, Immunohistochemical stain for tryptase. D, Immunohistochemical stain for chymase. Journal of Allergy and Clinical Immunology 1997 100, S25-S32DOI: (10.1016/S0091-6749(97)70001-0) Copyright © 1997 Mosby, Inc. Terms and Conditions