Change in secondary endpoints over time: (A) LS mean change from baseline in DAS28-CRP through Week 32, (B) mean change from baseline in CRP through Week.

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Change in secondary endpoints over time: (A) LS mean change from baseline in DAS28-CRP through Week 32, (B) mean change from baseline in CRP through Week 32, and (C) median change from baseline in HAQ-DI through Week 32. Change in secondary endpoints over time: (A) LS mean change from baseline in DAS28-CRP through Week 32, (B) mean change from baseline in CRP through Week 32, and (C) median change from baseline in HAQ-DI through Week 32. LS: least squares; DAS28: Disease Activity Score at 28 joints; CRP: C-reactive protein; HAQ-DI: Health Assessment Questionnaire-Disability Index; PBO: placebo. Philip J. Mease et al. J Rheumatol 2018;45:22-31 ©2018 by The Journal of Rheumatology